| 银杏内酯B注射液大鼠药代动力学研究 |
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| 引用本文： | Zhang XT,Jiao HY,Suo QL. 银杏内酯B注射液大鼠药代动力学研究[J]. 中药材, 2012, 35(3): 430-433 |
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| 作者姓名： | Zhang XT Jiao HY Suo QL |
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| 作者单位： | 广东省中药研究所创新药物研究中心 |
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| 基金项目： | 国家自然科学基金(81001384);广东省自然科学基金(S2011010001294);广东省科技计划项目(2010B030700020);广州市科技计划项目(2010GN-C041) |
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| 摘 要： | 目的:研究大鼠静脉注射银杏内酯B注射液后的药代动力学。方法:采用LC-MS法测定银杏内酯B经时血药浓度,采用DAS2.0实用药代动力学程序计算其药代动力学参数。结果:大鼠单次静脉注射低、中、高(0.75、3.75、14.0 mg/kg)三个剂量银杏内酯B注射液,银杏内酯B主要药代动力学参数:Tmax均为(0.083±0)h,Cmax均值分别为(422.312±14.203)、(1608.467±226.677)、(1987.036±237.202)μg/L,AUC0-t均值分别为(533.833±114.943)、(1786.029±137.066)、(1943.44±415.892)μg.h/L。结论:各剂量组血药浓度试验数据经拟和优度分析,药物消除符合三室模型,AUC0-t、AUC0-∞、Cmax随剂量的增加而不成比例增加,说明银杏内酯B注射药液给药后在大鼠体内呈非线性动力学消除过程。
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| 关 键 词： | 银杏内酯B注射液 血药浓度 药代动力学 LC-MS 大鼠 |
Study on the pharmacokinetics of ginkgolide B for injection in rats |
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| Zhang Xian-Tao,Jiao Hao-Yan,Suo Qi-Liang. Study on the pharmacokinetics of ginkgolide B for injection in rats[J]. Journal of Chinese medicinal materials, 2012, 35(3): 430-433 |
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| Authors: | Zhang Xian-Tao Jiao Hao-Yan Suo Qi-Liang |
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| Affiliation: | Guangdong Research Institute of Traditional Chinese Medicine, Guangzhou 510520, China. zxtcpu@yahoo.com.cn |
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| Abstract: | Objective:To study the pharmacokinetics of ginkgolide B for injection in rats.Methods:The serum concentration of ginkgolide B was determined by LC-MS and calculate its parameter of pharmacokinetics via DAS2.0 software.Results:After intravenous of 0.75 、3.75 and 14.0 mg/kg ginkgolide B,parameters of pharmacokinetics of ginkgolide B were:Tmax were all(0.083±0)h,Cmax were(422.312±14.203),(1608.467±226.677),(1987.036±237.202) μg/L,AUC0-t were(533.833±114.943)、(1786.029±137.066)、(1943.44±415.892) μg·h /L.Conclusion:Ginkgolide B has three compartment model in rats. |
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| Keywords: | Ginkgolide B for injection Plasma drug concentration Pharmacokinetics LC-MS Rats |
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