Diet and syndrome X |
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Authors: | Gerald M Reaven MD |
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Institution: | (1) Division of Cardiovascular Medicine, Falk CVRB, Stanford Medical Center, 300 Pasteur Drive, 94305 Stanford, CA, USA |
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Abstract: | Syndrome X is a cluster of abnormalities, associated with resistance to insulin-mediated glucose uptake, that increases risk
of coronary heart disease. Increased carbohydrate intake (with reciprocal decreased fat intake) within the boundaries of menus
that can be followed in the free-living state have not been shown to decrease insulin resistance directly, by enhancing insulin
sensitivity, or indirectly, by producing and maintaining weight loss. Moreover, such diets accentuate the metabolic abnormalities
that constitute Syndrome X. Substitution of monounsaturated fat, polyunsaturated fat, or both for saturated fat results in
the same reduction in low-density lipoprotein-cholesterol concentration as seen in diets low in fat and high in carbohydrates
but without any untoward effects on the various manifestations of Syndrome X. Consequently, substituting unsaturated fat for
saturated fat, without increasing intake of dietary protein or carbohydrate, may be useful for patients with hypercholesterolemia,
Syndrome X, or both. |
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Keywords: | |
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