survivin在食管鳞状细胞癌中的表达及其与bcl-2,bax表达的相关性

目的:探讨凋亡抑制基因survivin在食管鳞状细胞癌(简称食管鳞癌)中的表达,及其与bcl-2、bax基因表达的相关性.方法:应用SP免疫组织化学法检测85例食管鳞癌组织及对应癌旁正常食管黏膜组织中survivin,bcl-2和bax蛋白的表达.结果:食管鳞癌组织中,survivin蛋白的表达率为77.64%,显著高于癌旁正常食管黏膜组织的表达率7.06%(P＜0.05).survivin蛋白表达与食管鳞癌的TNM分期及淋巴结转移有关(P＜0.05).survivin表达与bcl-2蛋白表达呈正相关(P＜0.05),而与bax蛋白表达无关(P＞0.05).结论:survivin在食管鳞癌的发生、发展中起重要作用,可能成为食管鳞状细胞癌基因治疗的新靶点.survivin基因可能与bcl-2基因在食管鳞癌的发展中协同作用.

Expression of survivin in esophageal squamous cell carcinoma and its correlation with bcl-2,bax

Objective:To explore the expression of survivin and its correlation with the expression of bcl-2, bax in esophageal squamous cell carcinomas(ESCC). Methods: Immunohis-tochemical method was used to determine the expression of survivin, bcl-2 and bax gene in 85 cases of ESCC tissues and tumor-adjacent normal mucosa tissues. Results: Survivin was expressed in 66 of 85(77.64%) cases of ESCC and in 6 of 85 (7.06 %) cases of normal tissues. Expression of survivin was significantly higher in ESCC than that in normal tissues(P<0.05). Overexpression of survivin was related to the tumor grade and lymphatic metastasis(P<0.05). Expression of survivin was positively correlation with bcl-2 (P<0.05), but not with bax expression (P>0.05). Conclusion: Survivin may play an important role in the pathway of carcinogenesis and progression of ESCC and it may be identified as a new therapeutic target. Survivin and bcl-2 may play synergetic roles in the developmeut of ESCC.