Selection of an Escherichia coli O157:H7 bacteriophage for persistence in the circulatory system of mice infected experimentally |
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| Authors: | R. Capparelli I. Ventimiglia S. Roperto D. Fenizia D. Iannelli |
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| Affiliation: | School of Biotechnology, University of Naples 'Federico II', Naples, Italy. |
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| Abstract: | A bacteriophage lytic for Escherichia coli O157:H7 was isolated from bovine manure. Following in-vivo selection, the phage acquired the capacity to persist in the circulatory system of mice for at least 38 days. When mice were infected experimentally with E. coli O157:H7 (10(7) CFU/mouse), simultaneous injection of the mice with phage (10(8) PFU/mouse) cleared E. coli O157:H7 from the mice within 48 h. |
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| Keywords: | Bacteriophage therapy Escherichia coli O157:H7 in-vivo selection mice persistence |
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