钆贝酸葡甲胺与钆喷替酸葡甲胺在肝脏MR增强扫描中安全性与耐受性的对比分析

目的　对Gd BOPTA与Gd DTPA在MR增强扫描中的安全性与耐受性进行对比分析。方法　超声或CT怀疑肝内原发肿瘤或肝转移瘤的病例共 42例进行MR检查。采用双盲、随机的试验方法 ,先进行给药前平扫 ,然后立即肘前或手背静脉注射任一种对比剂 ,注射剂量 0 .1mmol/kg ,注射速度 >1.0ml/s。随后进行给药后的MR动态及延迟扫描。每一病例在给药前 7天及给药后 2 4h分别进行病史及体格检查、生命体征的检查以及血、尿常规和生化检查 ,并进行统计学分析 ,对此期间的任何不良事件进行监测和记录。结果　所有病例在给药前后均无任何明显不适反应 ,其生命体征及血、尿常规和生化检查均无显著性差异。结论　在肝脏MR增强扫描中 ,Gd BOPTA与Gd DTPA均具有良好的安全性与耐受性。

Comparison of Safety and Tolerance of Gd-BOPTA with Gd-DTPA in Contrast-Enhanced MR Imaging of Liver

Objective To compare the safety and tolerance of Gd-BOPTA with Gd-DTPA in contrast-enhanced MR imaging.Methods Forty-two cases suspected of preliminary liver tumor or hepatic metastases by US or CT were studied by pre- and post-contrast MRI.Pre-contrast images were acquired firstly,then either Gd-BOPTA or Gd-DTPA was intravenous injected at the same dose of 0.1 mmol/kg.Dynamic and delayed images after injection were obtained.Physical examinations,vital signs,and laboratory tests were acquired 7 days before and 24 hours after injection,respectively.The results were analyzed statistically.Results No patients has any uncomfortable reaction in this study,and the results of blood and urine tests of all the cases did not have any significant difference.Conclusion Both Gd-BOPTA and Gd-DTPA were well safe and tolerated in contrast-enhanced MR imaging of liver.