Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility |
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| Authors: | Francesca Fernandez Teresa Esposito Rod A Lea Natalie J Colson Alfredo Ciccodicola Fernando Gianfrancesco Lyn R Griffiths |
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| Affiliation: | (1) Genomics Research Centre, Griffith Institute for Health and Medical Research, Griffith University, Gold Coast, Queensland, Australia;(2) Institute of Genetics and Biophysics, Adriano Buzzati-Traverso, CNR, Naples, Italy;(3) Institute of Environmental Science and Research, Wellington, New Zealand |
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| Abstract: | Background Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the number and type of genes involved is still unclear. Prior linkage studies have reported mapping of a migraine gene to chromosome Xq 24–28, a region containing a cluster of genes for GABA A receptors (GABRE, GABRA3, GABRQ), which are potential candidate genes for migraine. The GABA neurotransmitter has been implicated in migraine pathophysiology previously; however its exact role has not yet been established, although GABA receptors agonists have been the target of therapeutic developments. The aim of the present research is to investigate the role of the potential candidate genes reported on chromosome Xq 24–28 region in migraine susceptibility. In this study, we have focused on the subunit GABA A receptors type ε (GABRE) and type θ (GABRQ) genes and their involvement in migraine. |
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