玉液汤对大鼠糖尿病的时间治疗学作用研究

目的观察玉液汤不同时间给药对糖尿病大鼠的影响,探索合适的用药时间。方法用链脲佐菌素腹腔注射制备糖尿病大鼠模型,通过正常大鼠与模型大鼠不同时间血糖值的不同,探索1 d中大鼠血糖变化情况,在此基础上,分不同时间给予模型大鼠玉液汤,观察各组大鼠血糖、胰岛素、C肽、甘油三酯、胆固醇等指标的变化。结果玉液汤早组(6:00给药组)在降低血糖、血脂,提高胰岛素和C肽含量方面较玉液汤晚组(18:00给药组)疗效要好。结论玉液汤在治疗糖尿病方面明显受时间因素的影响,通过改变给药时间可以明显提高疗效。

The Effect of Yuye Decoction on the Time Therapeutics in Diabetic Rats

Objective To observe Yuye Decoction curative effect to different administer time's influence on diabetes rats' blood sugar.We explore the appropriate administer time.Methods This experiment made diabetes model through intraperitoneal injection of streptozotocin to rats.At first we explored rats' blood sugar variation in one day passing different value of blood sugar of the healthy rats and the model rats different time.In this foundation,we feed the model rats to Yuye Decoction in different time.After that,we collected the blood sample of different groups of rats through picking the eyeball and observe the change of the blood sugar,the insulin,the C peptide,the glycerin as well as the cholesterol.Results The Yuye Decoction early group(6: 00 gives the medicine group) has better curative effect than the late group(18: 00 gives the medicine group)in some aspects which include in reducing the blood sugar and the blood fats,enhancing the insulin and the C peptide content.Conclusion Yuye Decoction is affected obviously by time factor in treating diabetes aspect,and applying the medicine through the different time may enhance obviously the curative effect.