反流性食管炎85例胃酸及胆汁反流的同步监测

目的：研究反流性食管炎（RE）患胃酸和胆汁反流的发生情况，以探讨其发病机制和指导临床实践。方法：RE患85例，健康志愿20例作对照，应用便携式PH计及胆汁监测仪同步监测食管24hpH值变化及胆汁反流情况。结果：RE患胃酸及胆汁反流均较对照组显增加；62．4％的RE患存在胃酸及胆汁混合反流，单纯胃酸反流为30．6％，单纯胆汁反流为3．5％，无任何反流为3．5％；男女之间比较，各种反流无差别。结论：胆汁反流与胃酸反流常见于RE患，在胃食管反流病的发生中起重要作用，同步动态监测食管PH值及胆汁变化对RE的诊断有重要意义。

Simultaneously monitoring acid and bile reflux in 85 patients with reflux esophagitis

Objective: To study the incidence of acid and bile reflux inpatients with reflux esophagitis(RE) and to evaluate the significance of detecting bile reflux in diagnosing RE. Methods: Using ambulatory 24 h pH monitoring bilirubin monitoring techniques, we simultaneously assessed the changes of intra-esophgeal pH and bile reflux during 24 h in 105 subjects(including 85 patients with RE and 20 volunteers). Results: The time of esophageal acid exposure(pH<4) for RE patients was significantly greater than that for controls. Bile reflux, represented by total percentage time of bilirubin absorbance≥0.14, was significantly greater for RE patients than that for controls. Neither acid nor bile reflux had difference between male and female. In RE patients, 62.4% had both acid and bile reflux; 30.6%, acid reflux; 3.5% , bile reflux; 3.5%, no reflux. Conclusion: Both acid and bile reflux are very common in RE patients and both may play roles in the development of RE. Simultaneously monitoring acid and bile reflux is very important in diagnosing RE.