266例可疑耐多药结核病人筛查情况分析与探讨

目的对266例可疑耐多药结核病患者进行耐多药筛查，并对结果分析和探讨。方法通过痰涂片及培养、菌鉴及药敏试验诊断耐多药结核。结果266例可疑患者耐药发生率53．3％，其中MDR-TB28．2％，DR—TB25．1％，MDR—TB复治失败病人比例最高。DR—TB初治3月末阳性比例最高。MDR—TB中，初治组耐HRES、HRS最多，复治组耐HR、HRES最多。结论复治组是发生MDR．TB主要类别，耐多药筛查可早期发现MDR—TB病人，为制定耐多药结核病防治对策提供参考依据。

Analysis and investigation of 266 suspicious tuberculosis patients with multi-drug resistance

Objective To screen the drug resistance of 266 suspicious tuberculosis patients with multi-drug resistance, and to analyze the results. Methods The drug resistance was test through the sputum smear and culture, bacteria identification and drug sensitivity test. Results The incidence of drug resistance was 53.3%, including 28.2% of MDR-TB and 25.1% of DR-TB. The re-treatment failure rate of NDR-TB patients was the highest. At the end of the third month after the initial treatment, the positive rate of DR-TB was the highest. HRES and HRS were found mostly in the initial treatment group of MDR-TB patients, and HR and HRES were found mostly in the re-treatment group. Conclusion The re-treatment group is the main group where MDR-TB occurs. Therefore, the MDR-TB patients can be found in the early stage by the multi-drug resistance screening which can provide the clinical references for the treatment of patients with multi-drug resistance tuberculosis.