Changes in antioxidant status of lung tissue in experimental diabetes in rabbits |
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| Authors: | Gumieniczek Anna Hopkała Hanna Wójtowicz Zbigniew Wysocka Monika |
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| Affiliation: | Department of Medicinal Chemistry, Medical University of Lublin, Chod?ki Str. 6, 20-093 Lublin, Poland. kzchl@asklepios.am.lublin.pl |
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| Abstract: | OBJECTIVES: Hyperglycaemia can result in oxidative stress which may affected as cellular tissue damage. DESIGN AND METHODS: After 3, 6, 12 and 24 weeks of hyperglycaemia oxidative stress related parameters were measured in lung tissue of diabetic and control rabbits. RESULTS: Decreased activities of antioxidative compounds and intensification of lipid peroxidation process were found in diabetic lung. CONCLUSIONS: The data obtained suggest that hyperglycaemia induces oxidative stress in lung tissue which may play an important role in pathogenesis of diabetic complications. |
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| Keywords: | Alloxan-diabetes Lung Antioxidative system |
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