Polyglandular endocrine failure in a patient with amyloidosis secondary to familial Mediterranean fever |
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| Affiliation: | 1. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States;2. Department of Medicine, University of Washington, Seattle, WA, United States;1. Institute for Water, Environment and Health, United Nations University, 175 Longwood Rd, Hamilton, ON L8P0A1, Canada;2. Sound Seas, Bethesda, MD 20816, USA;3. College of Marine Science, University of South Florida, St. Petersburg, FL 33701, USA;4. Conservation Biology Division, Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, 2725 Montlake Blvd E, Seattle, WA 98112, USA;5. Fisheries, Aquaculture and Marine Ecosystems Division, Secretariat of the Pacific Community, B.P. D5, 98848 Noumea Cedex, New Caledonia;6. School of Marine and Environmental Affairs and Jackson School of International Studies, University of Washington, Seattle, WA 98105-6715, USA;7. Global Change Institute, University of Queensland, St. Lucia, Qld 4072, Australia;8. School of Biological Sciences, University of Queensland, St. Lucia, Qld 4072, Australia;9. School of the Environment, University of Technology, Sydney, PO Box 123, Broadway, NSW 2007, Australia;10. Stockholm Resilience Centre, Stockholm University, SE-106 91 Stockholm, Sweden;11. School of International Development, University of East Anglia, Norwich NR4 7HU, UK;12. School of Arts and Social Sciences, James Cook University, Townsville, Qld 4811, Australia;13. Dept. of Education & Interdisciplinary Studies, Florida Institute of Technology, Melbourne, FL 32901, USA;14. School of Forest Resources and Conservation, University of Florida, Gainesville, FL 32653, USA;15. Agricultural and Resource Economics/CT Sea Grant, University of Connecticut-Avery Point, Groton, CT 06340, USA;p. Crawford School of Public Policy, Australian National University, Canberra, ACT 0200, Australia;q. Centre for Public, International and Comparative Law, and TC Beirne School of Law, University of Queensland, St. Lucia, Qld 4072, Australia;r. School of Biology, Newcastle University, Newcastle upon Tyne NE1 7RU, UK;s. CORDIO East Africa, BOX 10135, Mombasa 80101, Kenya;t. Swire Institute of Marine Science, University of Hong Kong, Cape d’Aguilar Road, Shek O, Hong Kong, China;u. School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK;1. Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA, USA;2. Department of Genome Sciences, University of Washington, Seattle, WA, USA;3. Department of Medicine, University of Washington, Seattle, WA, USA;1. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Hyderabad, Balanagar, India;2. Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, India;3. Pharmacology Division, Indian Institute of Chemical Technology (IICT), Hyderabad, India;4. Division of Neurology, Department of Medicine, University of Alberta, 2E3.26 Walter C Mackenzie, Health Sciences Center, Edmonton, AB, T6G 2B7, Canada |
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| Abstract: | Familial Mediterranean fever (FMF) is 1 of the major causes of secondary amyloidosis. Renal involvement is the main clinical complication and it mostly presents with nephrotic syndrome and chronic renal failure. Although deposition of amyloid has been reported in several endocrine glands such as the adrenal, thyroid, and testes, clinically significant functional impairment is uncommon. Herein, we describe a patient in whom the diagnosis of FMF was based on molecular screening and who presented with recurrent hypoglycemic attacks and extensive amyloid deposition affecting various organ function including adrenal, thyroid, parathyroid, testes, intestinal system, and the heart. © 2001 by the National Kidney Foundation, Inc. |
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| Keywords: | Hypoglycemia polyglandular endocrine failure renal failure secondary amyloidosis |
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