妊高征与正常妊娠母血与脐血-一氧化氮水平的比较

目的：比较妊娠高血压综合征（妊高征，ＰＩＮ）和正常妊娠时母静脉血与脐动脉 血中一氧化氮（ＮＯ）水平。方法：用紫外分光光度计分别对２８例妊高征患者母血和５０例 正常妊娠的母血及２８例妊高征分娩时济动脉血及正常妊娠３２例脐动脉动血中一氧化氮 的稳定的代谢产物──亚硝酸盐进行了测定。结果：妊高征时母血亚硝酸盐水平显著低 于正常妊娠妇女（Ｐ＜０．０５）；但妊高征脐血中亚耙酸盐水平高于正常妊娠组（Ｐ ＜ ０．０５）。 结论；孕期ＮＯ生成量下降可能参与妊高征的病理机制；妊高征时脐动脉血中ＮＯ水平升 高，可能是针对其胎盘功能障碍的一种代偿性反应。

Comparisons of Maternal and Umbilical Plasma Nitrite Levels in Normal Pregnant and Pregnancy-Induced Hypertension Women

Objective: To make comparisons of maternal venous and umbilical artery plasma nitric oxide levels, an index of nitric oxide synthesis, between normal pregnant and pregnancy- induced hypertension (PIH) women. Methods: 28 PIH women and 50 normal pregnant women were included in the study. Maternal venous blood was collected from all the subjects. Umbilical artery blood was obtained from 28 PIH and 32 normal pregnant women soon after their delivery. Plasma nitrite levels were determined by spectrophotometry. Results: Maternal venous nitrite levels were significantly lower in PIH than in normal pregnant women(p < 0. 05 ). On the other hand, umbilical nitrite levels were significantly higher in PIH than in normal pregnant women(P < 0. 05 ). Conclusions: The reduced synthesis of nitric chide in maternal veins might be involved in the mechanism of PIH, and the increased nitric oxide production in umbilical artery in PIH might be a compensatory response to the defective placenta function.