Effect of fusidic acid on migration and chemiluminescence of polymorphonuclear leukocytes |
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| Authors: | A. Næss R. W. Flø C. O. Solberg |
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| Affiliation: | (1) Medical Department B, Haukeland Hospital, University of Bergen, N-5021 Bergen, Norway |
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| Abstract: | Incubation of polymorphonuclear leukocytes (PMNs) in fusidic acid resulted in a decrease of random migration and chemiluminescence. The effects were dose-dependent but moderate, with statistical significance only at concentrations of 50 mg/l or more. At concentrations used for therapy of bacterial infections and AIDS, fusidic acid was not shown to be deleterious to these aspects of PMN function. |
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