| 针对肾素-血管紧张素-醛固酮系统的抗高血压治疗新靶点 |
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| 引用本文： | 彭猛,蒋雄京.针对肾素-血管紧张素-醛固酮系统的抗高血压治疗新靶点[J].心血管病学进展,2011,32(1):13-16. |
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| 作者姓名： | 彭猛 蒋雄京 |
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| 作者单位： | 北京协和医学院,阜外心血管病医院,心内科,北京,100037 |
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| 摘 要： | 尽管近几十年来抗高血压治疗取得了显著的成就,高血压仍是全世界面临的重大挑战,为了寻求更好降压及降压以外的心血管保护,进一步降低心血管风险,有必要研发更有效控制血压的新方法。肾素-血管紧张素-醛固酮系统的调控是目前抗高血压治疗最重要的基石,现阐述针对肾素-血管紧张素-醛固酮系统的抗高血压治疗新靶点,包括血管紧张素Ⅱ的2型受体、中性肽链内切酶、醛固酮合成酶、肾胺酶、肾素（原）受体、肾脏去神经支配、疫苗、血管紧张素转换酶2等。
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| 关 键 词： | 高血压 治疗 肾素-血管紧张素-醛固酮系统 |
Novel Renin-angiotensin-aldosterone-system-related Targets for Antihypertensive Therapy |
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| PENG Meng,JIANG Xiong-jing.Novel Renin-angiotensin-aldosterone-system-related Targets for Antihypertensive Therapy[J].Advances in Cardiovascular Diseases,2011,32(1):13-16. |
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| Authors: | PENG Meng JIANG Xiong-jing |
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| Institution: | PENG Meng,JIANG Xiong-jing(Department of Cardiology,Fuwai Hospital,Peking Union Medical College,Chinese Academy of Medical Science,Beijing 100037,China) |
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| Abstract: | In order to improve blood-pressure and to achieve further risk reduction（beyond blood-pressure control）,new methods of blood pressure reduction are still needed.Modulation of the renin-angiotensin-aldosterone system（RAAS） provides the rationale for current antihypertensive therapies.This review focuses on novel RAAS-related targets for antihypertensive therapy such as angiotensin Ⅱ type 2 receptors,neutral endopeptidase,aldosterone synthase,renalase,A（pro）renin-receptor,renal denervation,vaccination,and angiotensin-converting enzyme 2. |
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| Keywords: | hypertension therapy renin-angiotensin-aldosterone system |
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