Secretory component and lactoferrin in pure pancreatic juice in chronic pancreatitis |
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Authors: | Dr Tetsuo Hayakawa MD Takaharu Kondo MD Tokimune Shibata MD Toshiyuki Murase MD Hideo Harada MD Koji Ochi MD Juntaro Tanaka MD |
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Institution: | (1) 2nd Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, 466 Nagoya, Japan;(2) Department of Laboratory Medicine, Okayama University, School of Medicine, Okayama |
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Abstract: | To evaluate pathophysiological roles of proteins in pancreatic secretion, immunoreactive lactoferrin (LF) and secretory component (SC) were measured in the first fraction of the pure pancreatic juice obtained endoscopically from 17 control, 21 suspected (SCP), 14 noncalcified (NCP), and 14 calcified chronic pancreatitis (CCP) subjects. The protein and amylase tended to decrease both in concentration and output from control to CCP. LF concentration was elevated in CCP (18.0±4.9 /ml) when compared with controls (2.3±0.2 g/ml), and LF output in NCP (12.3±3.8 g/min) was increased from controls (3.8±0.6 g/min). The combination of high LF concentration with low protein output was observed in 10/14 in CCP but 0/14 in NCP and can be a biochemical discriminator of CCP from NCP. SC concentrations were also elevated in NCP (8.5±2.0 g/ml) and CCP (5.6±1.6 g/ml) from controls (1.2±0.2 g/ml). SC outputs in SCP (9.8±3.1 g/min) and NCP (21.1±4.8 g/min) were increased from controls (1.7±0.3 g/min), but there was no further increase in CCP. Hypersecretion of LF and SC in chronic pancreatitis is different, especially in CCP, although the mechanisms for hypersecretion are unknown.This study was supported in part by a research grant for intractable pancreatic disease from the Ministry of Health and Welfare, Japan. |
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Keywords: | chronic pancreatitis pancreatic juice secretory protein lactoferrin secretory component amylase |
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