| 还原型谷胱甘肽对早期糖尿病肾病微炎症及尿清蛋白排泄率的影响 |
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| 引用本文： | 魏娜,沈学飞,薛迪中. 还原型谷胱甘肽对早期糖尿病肾病微炎症及尿清蛋白排泄率的影响[J]. 中国全科医学, 2011, 14(23) |
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| 作者姓名： | 魏娜 沈学飞 薛迪中 |
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| 作者单位： | 1. 武警河南省总队医院心肾科,河南省郑州市,450052
2. 中国人民解放军401医院崂山分院肾内科 |
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| 摘 要： | 目的 观察还原型谷胱甘肽对早期糖尿病肾病(DN)患者炎症因子和尿清蛋白排泄率的影响.方法 将60例DNⅢ期患者随机分为治疗组和对照组,所有患者均控制饮食、适当运动、采用胰岛素控制等一般对症治疗,治疗组患者同时静脉滴注还原型谷胱甘肽,1.2 g/d;对照组患者同时静脉滴注血塞通,1.2 g/d,均治疗4周.治疗前及治疗4周后检测血清C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子-a(TNF-a)和尿清蛋白排泄率,以20例健康体检正常者作为正常对照组.结果 治疗前两组患者的血CRP、IL-6、TNF-a水平均显著高于正常对照组,差异有统计学意义 (P＜0.01),而两组患者上述各指标水平间差异无统计学意义(P＞0.05).治疗4周后,对照组患者血清CRP、IL-6、TNF-a水平无明显改变(P＞0.05),而治疗组患者血清CRP、IL-6、TNF-a水平均显著降低(P＜0.05),但仍显著高于正常对照组(P＜0.05).治疗前两组患者的UAER间差异无统计学意义(P＞0.05),治疗后两组患者的UAER间差异有统计学意义(P＜0.05).治疗后,治疗组UAER较治疗前显著降低(P＜0.05),而对照组UAER治疗前后无显著变化(P＞0.05).结论 早期DN患者存在炎症状态和血管内皮功能损伤,还原型谷胱甘肽可减轻DN患者的炎症状态,降低尿清蛋白排泄率,对早期DN患者有重要保护作用.
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| 关 键 词： | 糖尿病肾病 还原型谷胱甘肽 白蛋白尿 炎症 |
Effects of Reduced Glutathione on the Microinflammation and Urinary Albumin Excretion Rate of Incipient Nephropathy |
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| WEI Na,SHEN Xue-fei,XUE Di-zhong. Effects of Reduced Glutathione on the Microinflammation and Urinary Albumin Excretion Rate of Incipient Nephropathy[J]. Chinese General Practice, 2011, 14(23) |
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| Authors: | WEI Na SHEN Xue-fei XUE Di-zhong |
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| Affiliation: | WEI Na,SHEN Xue-fei,XUE Di-zhong.Deparment of Cardiology-Nephrology,Armed Police Force Hospital of Henan,Zhengzhou 450052,China |
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| Abstract: | Objective To investigate the effects of reduced glutathione on inflammatory factors and urinary albumin excretion rate in treating incipient nephropathy among type 2 diabetic patients.Methods Sixty cases of type 2 diabetics with microalbuminuria were randomly assigned into two groups and all subjects received general treatment including diet control,exercises,and insulin.Patients in the trial group received reduced glutathione(1.2 g/d) intravenously for four weeks;while those in the control group received X... |
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| Keywords: | Diabetic nephropathy Reduced glutathione Albuminuria Inflammation |
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