低氧与成骨及破骨细胞代谢

背景:越来越多的研究发现低氧与骨质疏松症的发生密切相关。目的:总结低氧对成骨及破骨细胞骨代谢的影响,进一步阐明低氧在骨质疏松症的发病机制。方法:以"hypoxia,bone metabolism,osteoclasts,osteoblasts,COPD,high altitude,osteoporosis"为英文关键词,以"低氧,骨代谢,成骨细胞,破骨细胞,慢性阻塞性肺疾患,高原,骨质疏松"为中文关键词,检索2007/2011PubMed数据库、万方资源数据库及维普期刊库有关低氧与骨代谢及骨质疏松症文献。结果与结论:低氧可以促进破骨细胞的生成,增强破骨细胞骨吸收能力。低氧对成骨细胞生成的影响与氧浓度及低氧持续时间有关。低氧主要通过诱导低氧诱导因子的产生,而激活其下游一系列基因的表达,调节成骨细胞生成及其功能。慢性阻塞性肺疾患引起的骨质疏松症与低氧、糖皮质激素的应用、全身炎症反应及其他因素有关,高原环境下引起的骨质疏松主要与低氧有关。

Hypoxia and the metabolism of osteoblast and osteoclast

BACKGROUND:More and more researches have demonstrated that hypoxia is closely associated to osteoporosis.OBJECTIVE:To summarize the effects of hypoxia on bone metabolism of osteoblast and osteoclast and to make further explanation about the mechanism of hypoxia in osteoporosis.METHODS:A computer-based online search of literatures published from 2007 to 2011 related to hypoxia associated with bone metabolism and osteoporosis was performed in PubMed database,Wanfang database and VIP database using the key words of "hypoxia,bone metabolism,osteoblasts,osteoclasts,chronic obstructive pulmonary disease,high altitude,osteoporosis" in English and in Chinese.RESULTS AND CONCLUSION:Hypoxia can promote the generation and bone resorption of osteoclasts.The effects of hypoxia on the generation of osteoclasts depend on oxygen concentration and duration of hypoxia.Hypoxia inducible factors activated primarily by hypoxia which can active the downstream gene expression to regulate the generation of osteoblasts and their functions.The osteoporosis resulted from chronic obstructive pulmonary diseases is related to hypoxia,glucocorticoid,systemic inflammatory response and other factors.The osteoporosis resulted from high altitude is mainly related to hypoxia.