基质金属蛋白酶与椎间盘的退变

背景:椎间盘细胞外基质的破坏是椎间盘退变的主要标志,已经证实这与主要基质金属蛋白酶的表达和活性上调有关。然而到目前为止对于基质金属蛋白酶家族的调节几乎没有系统的资料。目的:全面了解基质金属蛋白酶在椎间盘退变中的表达及作用。方法:由第一作者用计算机检索中国生物医学全文数据库(SinoMed:2000/2011)和Medline数据库(2000/2011),检索词分别为"基质金属蛋白酶,基质金属蛋白酶组织抑制因子,椎间盘,退行性变,脊柱"和"matrix metalloproteinases,tissue inhibitor of matrix metalloproteinases,disc,degeneration,intervertebral"。共检索到207篇文章,按纳入和排除标准对文献进行筛选,共纳入31篇文章。回顾收录的基质金属蛋白酶相关综述和论文报告,并分析生物学作用及调节的研究进展。结果与结论:基质金属蛋白酶在椎间盘退变中起着重要作用,已有证据表明基质金属蛋白酶能加速椎间盘细胞外基质的退变进程,并已取得了大量免疫组化证据的支持。

Matrix metalloproteinases and disc degeneration

BACKGROUND:The disruption of the extracellular disc matrix is a major hallmark of disc degeneration.This has previously been shown to be associated with an up-regulation of major matrix metalloproteinase expression and activity.However,until now hardly any data are available for matrix metalloproteinase regulation and thereby no concept exists as to which matrix metalloproteinase plays a major role in disc degeneration.OBJECTIVE:To understand the expression and role of matrix metalloproteinase in intervertebral disc degeneration.METHODS:matrix metalloproteinase relevant articles from Chinese Biomedical Literature Database and Medline database 2000/2010 were retrieved by the first author using Key words "matrix metalloproteinases,tissue inhibitor of matrix metalloproteinases,disc,degeneration,spine,intervertebral" in Chinese and English.A total of 207 papers were retrieved.According to inclusion and exclusion criteria,31 papers were included in the final.Then,the development of matrix metalloproteinase expression and regulation on intervertebral disc degeneration was studied.RESULTS AND CONCLUTION:With deeply research,matrix metalloproteinase may play an important role in intervertebral disc degeneration.There are some evidences to indicate that matrix metalloproteinase can accelerate the progression of disc excellular matrix degeneration