呼吸机膜材料的选择及其生物相容性

背景：随着医学和组织工程技术发展,各种生物材料相继出现,如何选择合适的膜材料成为人工肺技术发展的关键。目的：评价各种呼吸机膜生物材料的应用性能,寻找合适的呼吸机膜材料。方法：采用电子检索的方式,在万方数据库（http：//www.wanfangdata.com.cn/）中检索1991-01/2011-12有关生物材料应用于呼吸机膜的研究文章,关键词为＂膜式,人工肺,生物材料＂。排除内容重复、普通综述及Meta分析类文章。共纳入20篇文献进行评价,中文文献11篇,英文文献9篇。结果与结论：目前人工肺膜的结构形式已从最初的卷筒式、平板折叠式发展到今天广为采用的微孔中空纤维膜式。用于制造中空纤维的材料主要为一些成纤性能良好的高分子材料,如聚丙烯、聚醚砜等。膜式人工肺可以提高气体交换能力和生物相容性。随着高新材料的开发、基础研究的深入和临床经验的积累,人工肺必将开创治疗重症呼吸系统疾患的新局面。

Selection and biocompatibility of ventilator membrane materials

BACKGROUND：With the advanced progress of medicine and tissue engineering technology,a variety of biomaterials have emerged,and how to choose the suitable membrane materials becomes the key for artificial lung technology development.OBJECTIVE：To evaluate the performance of various ventilator membrane biomaterials,and to find the appropriate materials.METHODS：An electronic retrieval of Wanfang database（http：//www.wanfangdata.com.cn/） from January 1991 to December 2011 was performed for articles about the biological materials applied in ventilator membrane research,using the key words for ＂film,artificial lung,biological material＂ in Chinese.Duplicated documents,reviews and Meta analysis were excluded.A total of 20 articles were involved in the evaluation,including 11 Chinese literatures and nine English literatures.RESULTS AND CONCLUSION：The structure of artificial lung membrane had been developed from drum,plate folding to microporous hollow fiber membrane which is widely used now.The hollow fiber materials are mainly polymers with high performance of fiber formation,such as polypropylene and poly（ether sulfone）.Membrane-type artificial lung can improve gas exchange and biocompatibility.With the development of new technologies and materials,the advance of basic research and the accumulation of clinical experience,artificial lung is bound to initiate new insight in the treatment of severe respiratory disorders.