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| 祖师麻止痛喷雾剂主要药效学研究 | |
| 引用本文： | 何家田,赵兴红,涂宏海,张建春,丁永刚.祖师麻止痛喷雾剂主要药效学研究[J].解放军药学学报,2012,28(2):118-120. |
| 作者姓名： | 何家田 赵兴红 涂宏海 张建春 丁永刚 |
| 作者单位： | 1. 兰州军区药品仪器检验所,甘肃兰州,730050 2. 新疆军区药品仪器检验所,新疆乌鲁木齐,830063 3. 解放军第一医院,甘肃兰州,730030 4. 兰州大学第二医院,甘肃兰州,730030 |
| 摘 要： | 目的研究祖师麻止痛喷雾剂的镇痛、抗炎、活血作用。方法采用小鼠热板法和甩尾法研究其镇痛作用;以二甲苯所致小鼠耳廓肿胀、角叉菜胶所致大鼠足跖肿胀的炎症模型研究抗炎作用;以大鼠血瘀模型研究活血作用。结果祖师麻止痛喷雾剂能够延长小鼠的辐射热甩尾潜伏期,增加热板法所致疼痛的痛阈时间,降低二甲苯所致的小鼠耳壳肿胀度,降低角叉菜胶所致大鼠足跖肿胀度,对大鼠血瘀模型有活血作用。结论祖师麻止痛喷雾剂具有明显的抗炎、镇痛、活血作用,可为临床应用提供实验依据。 |
| 关 键 词： | 祖师麻止痛喷雾剂 药效学 镇痛 抗炎 活血 |
Pharmacodynamics of Zushima Zhitong Spray |
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| HE Jia-tian , ZHAO Xing-hong , TU Hong-hai , ZHANG Jian-chun , DING Yong-gang.Pharmacodynamics of Zushima Zhitong Spray[J].Pharmaceutical Journal of Chinese People's Liberation Army,2012,28(2):118-120. | |
| Authors: | HE Jia-tian ZHAO Xing-hong TU Hong-hai ZHANG Jian-chun DING Yong-gang |
| Institution: | ①Institute for Drug and Instrument Control of Lanzhou Military Region,Lanzhou 730050,China; ②Institute for Drug and Instrument Control of Xinjiang Military Region,Urumqi 830063,China; ③The First Hospital of PLA,Lanzhou 730030,China; ④The Second Hospital of Lanzhou University,Lanzhou 730030,China |
| Abstract: | Objective To study the analgesic,anti-inflammatorg and blood-flow-promoting action of the Zushima Zhitong Spray.Methods The analgesic effect was tested by the hot-plate and tail-flick in mice.The anti-inflammatory effect was determined by observing mice,swelling of auricle induced by dimethylbenzene and rats′ podedema model induced by carrageenan.Rats with blood stasis were used to study the action of promoting blood flow.Results Zushima Zhitong Spray lengthened the delitescence of tail-flick caused by radiant heat,raised hot pain threshold in mice,alleviated mice′ swelling of auricle induced by dimethylbenzene and rats′ podedema induced by carrageenan,and promoted blood flow of blood stasis in rats.Conclusion Zushima Zhitong Spray has marked analgesic,anti-inflammatory and blood-flow-promoting effect. |
| Keywords: | Zushima Zhitong Spray pharmacodynamics promoting blood flow analgesia anti-inflammatory |
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