万古霉素血药浓度监测的临床应用

目的探讨万古霉素血药浓度监测的临床应用,以指导临床合理用药。方法对海军总医院2009年7月～2011年9月住院患者使用万古霉素的79例次血药浓度监测结果进行回顾性分析。结果该院住院患者使用万古霉素的总有效率为61.76%。血液中药物谷浓度在5～10 mg/L的占22.78%;小于5 mg/L有4例次,占5.06%;大于20 mg/L有27例次,占34.18%。结论根据血药浓度制定个体化给药方案,能提高疗效,减少不良反应。

Clinical Application of Blood Concentration Monitoring of Vancomycin

Objective To investigate the clinical application of blood concentration monitoring to guide rational use of vancomycin.Methods The results of blood concentration monitoring of 79 patients with vancomycin use from Jul.2009 to Sept.2011 were analyzed retrospectively.Results The total response rate of vancomycin was 61.76%.The concentrations of 22.78% of the cases was 5-10 mg/L,that of 5.06% was below 5 mg/L and that of 34.18% was over 20 mg/L.Conclusion It is important to formulate individualized dosing regimens based on the blood vancomycin level,which can ensure clinical efficacy and reduce incidence of toxicities.