脉冲电磁场对成骨和破骨代谢的影响

背景：脉冲电磁场对成骨细胞、破骨细胞、骨基质合成均有明显作用。目的：旨在探究脉冲电磁场在成骨和破骨代谢中的作用以及治疗骨质疏松的机制,以促进其临床应用。方法：由第一作者应用计算机检索PubMed、中国期刊全文数据库（CNKI）、维普数据库和万方数据库1997-05/2011-08相关文献。在标题、摘要、关键词中以＂pulsed electromagnetic field（PEMFs）,bone metabolism,osteoporosis,osteoblast,osteoclast,bone marrow mesenchymal stem cells（BMMSCs）＂或＂脉冲电磁场,骨代谢,骨质疏松,成骨细胞,破骨细胞,骨髓间充质干细胞＂为检索词进行检索。选择文章内容与脉冲电磁场有关者,同一领域文献则选择近期发表在权威杂志文章进行分析。结果与结论：初检得到389篇文献,根据纳入标准选择关于假体无菌性松动分析及处理的46篇文献进行综述。脉冲电磁场可促进成骨代谢,抑制破骨代谢,参与调节转化生长因子β,白细胞介素6等骨代谢相关的细胞因子,促进骨基质形成,改善骨生长微环境,对骨髓间充质干细胞的增殖分化亦有促进作用。推测脉冲电磁场治疗骨质疏松及其并发症有重要的临床价值。

Effects of pulsed electromagnetic field on osteogenic and osteoclastic metabolism

BACKGROUND： The pulsed electromagnetic field can influence the osteoblast, osteoclast, and the bone matrix synthesis. OBJECTIVE： To explore the mechanism of the pulsed electromagnetic field for treatment of osteoporosis in order to promote its clinical application. METHODS： A computer-based online search of PubMed database, CNKI database, VIP database and Wanfang database from May 1997 to August 2011 was performed to search related articles with the key words of ＂pulsed electromagnetic fields （PEMFs）, bone metabolism, osteoporosis, osteoblast, osteoclast, bone marrow mesenchymal stem cells （BMSCs）＂ in English and in Chinese by screening titles and abstracts. Articles related to pulsed electromagnetic field were selected. The documents published recently or in authoritative journals in the same field were preferred. RESULTS AND CONCLUSION： A total of 389 literatures were obtained in initial retrieval, and 46 documents of them concerning the analysis and treatment of aseptic loosening of aseptic prosthesis were involved to summarize according to inclusion criteria. PEMFs can promote osteogenic metabolism, inhibit osteoclastic metabolism, regulate transforming growth factor β and Interleukin 6, promote bone matrix synthesis, improve the micro-environment for bone growth, as well as facilitate proliferation and differentiation of BMSCs. PEMFs have an important clinical value of treatment for osteoporosis and its complications.