人工生物材料修复肌腱急性损伤及预防粘连

背景：肌腱损伤后的治疗措施经历了传统物理疗法、药物疗法以及现代组织工程学人工韧带的重建等漫长过程。目的：综述人工生物材料干预治疗肌腱粘连的措施,并探讨肌腱治疗过程中粘连的发生机制。方法：应用计算机检索万方、维普数据库和PubMed数据库中1990-01/2011-04与肌腱康复措施及材料学相关的文章,在标题和摘要中以＂肌腱,治疗,材料,粘连＂或＂tendon,treatment,materials,adhesion＂为检索词进行检索。选择文章内容与肌腱治疗材料学相关,同一领域文献则选择近期发表或发表在权威杂志文章。初检得到287篇文献,根据纳入标准选择21篇文章进行综述。结果与结论：人工韧带的重建与再生为严重的肌腱治疗与康复提供了可能和保障,但理想人工韧带材料的选择和研制成为治疗的关键,合成材料可以避免单一材料性能的不足,为材料的研制提供了广阔的发展空间,目前,基因治疗技术的发展也为肌腱组织工程技术提供了崭新的研究方向。另外,肌腱在治疗康复过程中往往发生粘连,严重影响着治疗效果,肌腱粘连与肌腱愈合的特点及其生理和病理有重要关系,采用生物材料作为预防粘连隔离物具有广阔的发展前景。

Biomaterials for repair and prevention of acute tendon injury and adhesion

BACKGROUND：Treatment measures for tendon injury experience a long process from traditional physical therapy,drug therapy to modern tissue engineering artificial ligament reconstruction.OBJECTIVE：To review the role of biological materials as artificial intervention in the treatment of tendon adhesion,and to explore the action mechanism.METHODS：VIP database,Wanfang database,and PubMed（1990-01/2011-04） were searched for articles related to tendon rehabilitation measures and biomaterials using the key words of ＂tendon,treatment,materials,adhesive＂ in Chinese and English.Articles related to materials for tendon treatment were retrieved,and those published recently or in authorized journals were preferred.Totally 287 articles were checked,and according to inclusion criteria 21 articles were reviewed.RESULTS AND CONCLUSION：Artificial ligament reconstruction and regeneration provides a chance and security for the treatment and rehabilitation of severe tendon injury.But the ideal artificial ligament material selection and development becomes the key.Synthetic materials can avoid the single material performance deficiencies,which provide a broad space for material development.At present,gene therapy technology development for tendon tissue engineering provides a new research direction.In addition,tendon adhesion often occurs during the treatment,and seriously affects the therapeutic effect.Tendon adhesion and healing has important relationship with the physiology and pathology of the tendon.Biomaterials as an adhesion prevention barrier have the vast developmental foreground.