心脑通口服液对全脑缺血再灌注损伤大鼠的保护作用

目的探讨心脑通口服液抗脑缺血的作用。方法用四动脉结扎法建立大鼠全脑缺血再灌注模型,观察心脑通口服液对脑缺血再灌注过程中脑电图及翻正反射恢复时间、脑含水量、脑指数的影响;对全脑缺血再灌注后脑组织匀浆丙二醛含量,超氧化物歧化酶、乳酸脱氢酶活性的影响。结果在全脑缺血再灌注大鼠模型上,心脑通口服液可以缩短翻正反射恢复时间,促进脑电的恢复;降低脑含水量和脑指数;提高脑组织超氧化物歧化酶、乳酸脱氢酶活性,降低丙二醛含量。结论心脑通口服液对缺血性脑损伤有一定的保护作用。

Protective Effects of XinnaotongOral Liquid on Global Cerebral Ischemia Reperfusion Injury

Objective To investigate the effect of Xinnaotong Oral Liquid on global cerebral ischemia reperfusion injury in rats and its mechanism.Methods The global cerebral isehemia/perfusion experiment induced by occlusion of four vessels for 10 min and reperfusion for 24 h was performed to observe the effect of Xinnaotong Oral Liquid on the recovery time of righting reflex and electrical activity of the brain,the water content and cerebral index,the activity of superoxide dismutase,lactate dehydrogenase and the content of maleic dialdehyde in brain tissue.Results Compared with model group,Xinnaotong Oral Liquid significantly promoted the recovery of electroencephalogram and righting reflex and reduced the brain edema and brain index obviously.Superoxide dismutase,lactate dehydrogenase activities increased while maleic dialdehyde content decreased in brain homogenate in rats treated by Xinnaotong Oral Liquid.Conclusion Xinnaotong Oral Liquid has protective effect on global cerebral ischemia reperfusion injury in rats.The role of antioxidation may be attributed to its neuroprotective effects.