| 恩替卡韦分散片的溶出度测定 |
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| 引用本文： | 吴素体,李正明,韩晋,袁海龙,吕俊兰,张诗龙.恩替卡韦分散片的溶出度测定[J].解放军药学学报,2012,28(1):60-62. |
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| 作者姓名： | 吴素体 李正明 韩晋 袁海龙 吕俊兰 张诗龙 |
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| 作者单位： | 1. 解放军302医院药学部,北京,100039
2. 100039北京,解放军302医院药学部;611731四川成都,成都中医药大学药学院 |
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| 摘 要： | 目的建立恩替卡韦分散片溶出度的HPLC测定方法。方法以0.05 mol/L磷酸二氢钾溶液250 ml为溶出介质,转速为50 r/min,取样时间为45 min,采用桨法测定恩替卡韦分散片的溶出度。结果恩替卡韦检测浓度的线性范围为0.5～10μg/ml(r=0.9999);方法专属性和精密度良好;平均回收率为99.91%,RSD为0.04%;3批样品45 min平均溶出度均在90%以上。结论该法操作简便,结果准确可靠,可用于恩替卡韦分散片的溶出度测定。
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| 关 键 词： | 恩替卡韦分散片 溶出度 HPLC |
Study on Dissolution of Entecavir Dispersible Tablets |
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| WU Su-ti
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LI Zheng-ming
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HAN Jin
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YUAN Hai-long
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LV Jun-lan
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ZHANG Shi-long.Study on Dissolution of Entecavir Dispersible Tablets[J].Pharmaceutical Journal of Chinese People's Liberation Army,2012,28(1):60-62. |
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| Authors: | WU Su-ti LI Zheng-ming HAN Jin YUAN Hai-long LV Jun-lan ZHANG Shi-long |
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| Institution: | ① ①Pharmacy Department,Military Hospital 302 of China,Beijing 100039,China ②College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611731,China |
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| Abstract: | Objective To establish an HPLC method for the determination of dissolution of entecavir dispersible tablets.Methods 250 ml 0.05 mol/L potassium dihydrogen phosphate was taken as the solvent at the rotating speed of 50 r/min,and the sampling time was 45 min.The dissolution of entecavir dispersible tablets was determined by oar method.Results The linear range of entecavir was 0.5-10.0 μg /ml（r=0.9999）,with an average recovery rate of 99.91%.RSD was 0.04%.The mean cumulative dissolution of three batches of entecavir dispersible tablets was above 90%.Conclusion The established method is simple,accurate and reliable for the determination of dissolution of entecavir dispersible tablets. |
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| Keywords: | entecavir dispersible tablets dissolution HPLC |
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