神经干细胞治疗小儿脑性瘫痪的研究进展

背景：神经干细胞移植给小儿脑性瘫痪的治疗带来了可能。目的：对国内外应用神经干细胞移植治疗的现状及新进展作一综述。方法：应用计算机检索CNKI和Pubmed数据库中1999-01/2011-04关于神经干细胞移植治疗脑瘫的文章,在标题和摘要中以＂脑瘫,神经干细胞,移植＂或＂cerebral palsy,neural stem cell,transplantation＂为检索词进行检索。选择文章内容与神经干细胞有关者,同一领域文献则选择近期发表或发表在权威杂志文章。初检得到119篇文献,根据纳入标准选择关于神经干细胞移植治疗脑瘫的28篇文献进行综述。结果与结论：神经干细胞特别是神经营养素3联合神经干细胞移植对小儿脑瘫的功能康复起着促进作用,给小儿脑瘫的今后的治疗指明了方向。

Research progress about neural stem cells transplantation for treatment of infantile cerebral palsy

BACKGROUND：Neural stem cells transplantation can be used to cure cerebral palsy（CP）.OBJECTIVE：To summarize the investigative situation and new progress about neural stem cells transplantation for the treatment of CP.METHODS：A computer-based research was performed on the CNKI database and PubMed database（1999-01/2011-04） to search the related articles about neural stem cells transplantation for CP.The key words were ＂cerebral palsy,neural stem cell,transplantation＂ in English and Chinese.The articles related to the neural stem cells transplantation for CP was selected,and for the articles in the same field,we selected the articles published recently or in the authorized journals.There were 119 articles after the initial survey.Then 28 articles related to neural stem cells transplantation were selected according to the inclusion criteria.RESULTS AND CONCLUSION：Neural stem cells transplantation combined with neurenergen 3 could promote the recovery of the function in the child with CP and point out the direction for the future treatment of CP.