SCI数据库关于神经干细胞移植治疗脊髓损伤研究的10年文献分析

背景：脊髓损伤是中枢神经系统的严重创伤,是目前公认的疑难病之一。组织工程细胞移植为脊髓损伤治疗提供了新的思路,使损伤轴突修复、再生和恢复脊髓部分神经功能成为可能。目的：利用SCI数据库文献检索和深度分析功能,对神经干细胞移植治疗脊髓损伤研究的10年文献资料进行多角度的探讨分析。设计：文献计量学分析。资料提取：由第一作者以＂neural stem cells（神经干细胞）,spinal cord injury or spinal injury（脊髓损伤）,cell transplantation（细胞移植）,spinal transection（脊髓横断）＂为关键词检索SCI数据库2002-01/2011-12的相关文献,并将分析结果及资料导出,以文字和图表的形式进行统计和计量分析,描述其分布特征。入选标准：纳入标准：检索神经干细胞移植治疗脊髓损伤研究相关的文献。文献类型包括研究原著、综述、会议记录及摘要、快报文章、编辑素材。排除标准：与文章目的无关的文献,大于10年较陈旧的文献,未发表的文章以及需电话追踪和手工检索逐一分析的文献。主要数据判定指标：以文献的类型、出版时间、发表文献的作者分布、学科类别、机构分布、国家地区分布、来源期刊、文献被引情况及基金资助机构进行相关分析。结果：SCI数据库2002/2011收录的文献中共检索到500篇神经干细胞移植治疗脊髓损伤研究相关的文献,研究原著以348篇位居首位,其中有15篇可以确定为经典文献。在时间分布上,文献数量2002/2011总体呈上升趋势,来源出版物呈分散情况,其中Journal of Neurotrauma《神经外伤杂志》发表文献量22篇,占全部文献的15.09%。其次为Journal of Neuroscience Research《神经科学研究杂志》21篇。结论：通过文献计量学方法对来源于SCI数据库关于神经干细胞移植治疗脊髓损伤研究的文献进行分析,可为了解该领域的概貌、现状和研究者进一步确定该领域研究的热点难点提供有价值的参考。

Literature analysis of neural stem cells transplantation for the treatment of spinal cord injury in the past 10 years based on Science Citation Index database

BACKGROUND：Spinal cord injury is a serious central nervous system trauma.Tissue engineered-cell transplantation provides a new approach for spinal cord injury,which make it possible for repairing or regenerating the injured axon and recovering partial of spinal functions.OBJECTIVE：To multivariately analyze the literature on neural stem cells transplantation for the treatment of spinal cord injury through Science Citation Index Database（SCI）.DESIGN：Bibliometric analysis.DATA RETRIEVAL：A computer-based retrieval was performed for the literature of neural stem cells transplantation for treating spinal cord injury during 2002-01 and 2011-12 in SCI.The retrieval results were analyzed,and the trends were described in words and graphics.INCLUSION CRITERIA：Articles on neural stem cells transplantation for the treatment of spinal cord injury include the following types：（1） Peer-reviewed original paper;（2） reviews;（3） meeting notes and abstracts;（4） proceeding papers;（5） editorial materials;（6） letters.Exclusive criteria were included：（1） Articles unrelated the study of neural stem cells transplantation for the treatment of spinal cord injury.（2） Articles published before 2002.（3） Articles which were not published on journals.（4） Articles which need to be retrieved by phone or manually.MAIN OUTCOME MEASUREMENTS：The literatures were analyzed by type of document,authors,publication year,journal distribution,discipline distribution,national distribution,institutional information,citation frequency and the fund agencies.RESULTS：A total of 500 literatures on neural stem cells transplantation for the treatment of spinal cord injury were retrieved in SCI database,in which most of paper were published as original articles（n=348）.Fifteen articles were identified as classic literature.The overall number of literature had an upward trend from 2002 to 2011.Journal of Neurotrauma published most papers in this field（n=22,15.09%）,followed by Journal of Neuroscience Research（n=21）.CONCLUSION：This paper provides a valuable reference for researchers to understand the overview and present situation of this field in order to set further research.