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胃癌组织中PTEN,MMP-9和Caspase-3表达的关系
引用本文:张丹丹,郭琳,王强. 胃癌组织中PTEN,MMP-9和Caspase-3表达的关系[J]. 世界华人消化杂志, 2006, 14(15): 1487-1492
作者姓名:张丹丹  郭琳  王强
作者单位:1. 中国医科大学附属第四医院胸外科,辽宁省,沈阳市,110032
2. 中国医科大学附属第二医院胃肠普通外科,辽宁省,沈阳市,110004
摘    要:目的:研究PTEN,MMP-9和Caspase-3在胃癌及正常胃组织中的表达,探讨他们在胃癌的发生、发展、浸润和转移中的作用.方法:选择临床病理资料齐全的胃癌蜡块标本54例,另取正常胃黏膜标本15例作对照.采用SP免疫组化方法检测PTEN,MMP-9和 Caspase-3在其中的表达.结果:胃癌中PTEN低表达(28/54,51.9%),且肿瘤浸润深(P=0.004)、有淋巴(P=0.003) 和远隔转移(P=0.01 5)、临床分期高(P= 0.001)、病理分化低(P=0.008)时降低.胃癌中MMP-9高表达(41/54,75.9%),且肿瘤浸润深(P=0.040)、有淋巴转移(P=0.025)、临床分期高(P=0.039)、病理分化低(P=0.009)时增高.胃癌中Caspase-3低表达(12/54,22.2%), 且有淋巴转移(P=0.045)、临床分期高(P= 0.015)、病理分化低(P=0.035)时降低.胃癌中PTEN与MMP-9(r=-0.543,P=0.001), Caspase-3与MMP-9的表达负相关(r=0.741, P=0.001),PTEN与Caspase-3的表达正相关(r =0.515,P=0.001).结论:胃癌中PTEN,Caspase-3低表达,MMP-9 高表达;PTEN、MMP-9和Caspase-3可作为胃癌诊断和预后判断的指标.

关 键 词:胃癌  PTEN  MMP-9  Caspase-3  免疫组织化学
收稿时间:2006-03-08
修稿时间:2006-03-08

Relationship among PTEN,matrix metalloproteinase-9,and Caspase-3 Expression in gastric carcinoma
Dan-Dan Zhang,Lin Guo,Qiang Wang. Relationship among PTEN,matrix metalloproteinase-9,and Caspase-3 Expression in gastric carcinoma[J]. World Chinese Journal of Digestology, 2006, 14(15): 1487-1492
Authors:Dan-Dan Zhang  Lin Guo  Qiang Wang
Abstract:AIM: To study the expression of PTEN, matrix metalloproteinase-9 (MMP-9), and Caspase-3 in gastric cancer, and to discuss their roles and correlations in the occurrence, development, invasion and metastasis of gastric cancer. METHODS: SP immunohistochemistry was used to measure the expression of PTEN, MMP-9, and Caspase-3 in 54 samples of gastric carcinoma selected from paraffin wax embodied specimens with complete clinicopathological data, and another 15 cases of normal gastric mucosa. RESULTS: The expression of PTEN in gastric cancer was low (28/54, 51.9%), and reduced with the increased invasive depth (P = 0.004) and clinical stages (P = 0.001), reduced histological differentiation (P = 0.008) and occurrence of lymph node (P = 0.003) and long distance metastasis (P = 0.015). The expression of MMP-9 in gastric cancer was high (41/54, 75.9%), and increased with increased invasive depth (P = 0.04) and clinical stages (P = 0.039), reduced his-tological differentiation (P = 0.009), and occurrence of lymph node metastasis (P = 0.025). The expression of Caspase-3 in gastric cancers was low (12/54, 22.2%), and reduced with increased clinical stages (P = 0.015), reduced histological differentiation (P = 0.035) and occurrence of lymph node metastasis (P = 0.045). The expression of PTEN and MMP-9 (r = -0.543, P = 0.001), Caspase-3 and MMP-9 (r = -0.741, P = 0.001) were in inversely correlation, while the expression of PTEN and Caspase-3 (r = 0.515, P = 0.001) were in positive correlation in gastric cancer. CONCLUSION: PTEN and Caspase-3 are lowly expressed in gastric caner, while MMP-9 is highly expressed. PTEN, MMP-9, and Caspase-3 can serve as the markers in the diagnosis and prognosis of gastric cancer.
Keywords:Gastric cancer  PTEN  Matrix metallo-proteinase-9  Caspase-3  Immunohistochemistry  
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