| 马兜铃酸相关中药材的探讨 |
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| 引用本文： | 鲁静.马兜铃酸相关中药材的探讨[J].中国药品标准,2002,3(2):49-50,61. |
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| 作者姓名： | 鲁静 |
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| 作者单位： | 中国药品生物制品检定所,北京,100050 |
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| 摘 要： | 目的：对关木通等相关中药材马兜铃酸的含有情况进行检测、分析。方法：采用高效液相色谱法。色谱条件：Platinum C18色谱柱；流动相：0．05mol/L磷酸二氢钠（含磷酸1ml/L）－腈（60：40）；检测波长：400nm。结果：17种相关中药材仅马兜铃属6种可检测出马兜铃酸类成分。细辛属（Asarum）、木通属（Akebia）、铁线莲属（Clematis）、风龙属（Sinomenium）、千金藤属（Stephania）、川木香属（Vladimiric）及云木香属（Aucklandic）相关植物中均未检出相应成分。结论：初步认为仅限于马兜铃属植物含有马兜铃酸类成分。木通的品种问题应进一步深入研究。
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| 关 键 词： | 关木通 马兜铃酸 高效液相色谱法 含量检测 |
STUDIES ON THE ARISTOLOCHIC ACID RELATED CRUDE TRADITIONAL CHINESE MEDICINE |
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| Authors: | Lu Jing |
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| Institution: | National Institute for the Control of Pharmaceutical and Biological Products, Beijing, China 100050 |
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| Abstract: | Objective: To detect aristolochic acid in 17 Kinds of related crude Traditional chinese Medicine. Method: The samples were analyzed by HPLC method using a Platinum C_(18)column,0.05mol/L NaH_2PO_4(containing 1ml of H_3PO_4 per liter)-acetonitrile(60:40)as the mobile phase and detecting wavelength 400nm.Result:aristolochic acid was founded in 6 species of Aristolochia,and not in the other species of Asarum,Akebia,Clematis,Sinomenium,Stephania,Vladimiric and Aucklandic geneses.Conclusion:It is considered that only Aristolochia species contain aristolochic acid.Further investigation and study should be carried out on the species of Mutong. |
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| Keywords: | Aristolochia and the related crude drugs aristolochic acid HPLC |
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