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Mode of transgene expression after fusion to early or late viral genes of a conditionally replicating adenovirus via an optimized internal ribosome entry site in vitro and in vivo
Authors:Rivera Angel A  Wang Minghui  Suzuki Kaori  Uil Taco G  Krasnykh Victor  Curiel David T  Nettelbeck Dirk M
Institution:Division of Human Gene Therapy, Department of Medicine, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Abstract:
Keywords:Viral vector  Viral oncolysis  Conditionally replicative adenovirus  Gene therapy  Armed oncolytic adenovirus  Early and late transgene expression  IRES  Timing of transgene expression
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