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Two grams daily of oral acyclovir reduces the incidence of cytomegalovirus disease in CMV-seropositive liver transplant recipients |
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| Authors: | J Gavalda` Jordi de Otero Enric Murio Victor Vargas José Rosselló Ignasi Calicó Carles Margarit Albert Pahissa |
| Institution: | (1) Division of Infectious Diseases, Hospital General Universitari Vall d'Hebron, Avda. Vall d'Hebron, 119–129, E-08 035 Barcelona, Spain Fax: + 34 3 428 2637 e-mail: jRgavalda@ar.vhebron.es, ES;(2) Division of Liver Transplantation, Hospitals Vall d'Hebron, Universitat Autònoma de Barcelona, E-08 035 Barcelona, Spain, ES;(3) Division of Hepatology, Hospitals Vall d'Hebron, Universitat Autònoma de Barcelona, E-08 035 Barcelona, Spain, ES;(4) Division of Preventive Medicine, Hospitals Vall d'Hebron, Universitat Autònoma de Barcelona, E-08 035 Barcelona, Spain, ES;(5) Division of Microbiology, Hospitals Vall d'Hebron, Universitat Autònoma de Barcelona, E-0803 5 Barcelona, Spain, ES |
| Abstract: | Our objective in this study was to determine the efficacy of 2 grams a day of oral acyclovir administered for 16 weeks after transplantation for the prevention of cytomegalovirus (CMV) infection and disease in CMV-seropositive liver transplant recipients. Seventy-three adult liver transplant recipients, seropositive for CMV, were randomized to receive either 2 grams a day of oral acyclovir for 16 weeks after transplantation or no prophylaxis. The incidence of CMV disease was significantly lower in the acyclovir group (5 %) than in the control group (27 %; P < 0.05). By log-rank analysis, the differences in the probability of presenting CMV disease over the first 16 weeks and over the 1st year were also significant (P < 0.05). We conclude that 2 grams a day of oral acyclovir provides effective prophylaxis against CMV disease in CMV-seropositive liver transplant recipients. Received: 14 March 1997 Received after revision: 30 May 1997 Accepted: 9 June 1997 |
| Keywords: | Acyclovir cytomegalovirus liver transplantation Liver transplantation cytomegalovirus acyclovir Cytomegalovirus liver transplantation acyclovir |
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