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Hu-ets-1 gene in congenital leukemia with t(11;19)(q23;p13) |
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| Authors: | Kazuma Ohyashiki Junko H. Ohyashiki Kazurshi Nomura Daniel H. Ryan Alan J. Kinniburgh Avery A. Sandberg |
| Affiliation: | a Department of Genetics and Endocrinology, Roswell Park Memorial Institute, Buffalo, NY, USA b Department of Human Genetics, Roswell Park Memorial Institute, Buffalo, NY, USA c Department of Hematology, University of Rochester Medical Center, Rochester, NY, USA |
| Abstract: | Cytogenetic analysis of the leukemic cells from a 1-day-old baby with an acute myelomonocytic leukemia revealed them to contain a chromosome change of t(11;19)(q23;p13). Molecular studies using a 980 bp HindIII/HpaI digested v-ets probe showed no DNA rearrangements, deletions, or amplification in the leukemic cells, including the JH immunoglobulin and T-cell receptor ( or β) genes. The findings indicate that the leukemic cells with t(11;19)(q23;p13) appear not to contain a transposition or rearrangement of the protooncogene Hu-ets-1 located at 11q23, as previously described in leukemic cells with t(4;11)(q21;q23) and t(9;11)(p22;q23). The leukemic cases with t(11;19)(q23;p13) studied by us showed a phenotype compatible with their myelomonocytic nature, although it is possible that other cases may have a lymphoid phenotype. |
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