376例慢性咳嗽患儿肺炎支原体检测结果分析

目的：分析慢性咳嗽患儿感染肺炎支原体的状况，为临床诊治儿童慢性咳嗽提供依据。方法：采用快速培养／药敏与间接凝集法检测慢性咳嗽患儿咽拭子和血清样本，回顾性分析376例患儿肺炎支原体培养和抗体检测结果。结果：在376例患儿中，肺炎支原体培养结果阳性率35．9％（135／376），抗体检测结果阳性率38．0％（143／376），两项联合检测总阳性率45．2％（170／376），联合检测阳性率高于单项检测，P〈O．05，差异有统计学意义；7岁以下小儿感染百分比明显高于7岁以上少年，P〈O．01，差异有统计学意义；根据药敏报告结合耐药趋势分析报告选取合适药物治疗后，所有感染肺炎支原体的慢性咳嗽患儿症状消除并痊愈。结论：肺炎支原体感染与性别无关，以7岁以下小儿多见，联合检测有利于提高诊断水平，根据药敏报告结合药敏趋势报告选药有良好的治疗效果。

The results analysis of mycoplasma pneumoniae detection in 376 children with chronic cough

Objective ： To investigate the clinical situations of mycoplasma pneumoniae infection in children with chronic cough and provide reference for clinical diagnosis. Methods ： Throat swab and serum specimens from children with chronic cough were detected with rapid culture or drug sensitivity and indirect agglutination. The results of mycoplasma pneumoniae culture and antibody test from 376 cases were analyzed retrospectively.Results ： Among the 376 children, positive rate for mycoplasma pneumoniae culture and antibody test were 35.9%（135/379）, 38.0%（143/376）, respectively. While the positive rate for pneumoniae culture combined with antibody test was 45.2%（170/376）. The positive rate of combined detection was significantly higher than that for single detection （p〈0.01）. Infection rate for children （〈7 years） was significantly higher than that for children （〉7 years） （p〈0.01）. Suitable treatments were adopted based on drug sensitivity and drug resistant tendency, and all the children with chronic cough recovered.Conclusi0ns ： Mycoplasma pneumoniae infection is not associated with gander, and mainly occurs in children （〈7 years）. Combined detection can help improve diagnostic accuracy and good therapeutic effect can be achieved according to doctor＇ s experience with dru~： sensitivity.