脂蛋白（a）和胱抑素C联合检测在2型糖尿病中的临床应用

目的：探讨脂蛋白（a）LP（a）]和胱抑素C（Cys-C）水平测定与2型糖尿病（T2DM）患者的病程、血糖控制水平的关系，以及2型糖尿病患者血清脂蛋白（a）与胱抑素C的相关性。方法：对150例（糖尿病组）患者进行血清LP（a）与Cys-C的水平检测，并与30例体检健康人群（对照组）进行对比分析。150例T2DM患者根据病程分为4组：15年组。结果：糖尿病组的血清LP（a）和Cys-C水平与对照组比较均有显著性差异（P15年组的组间血清LP（a）和Cys-C水平两两比较均有显著性差异（P〈0.05）；血清LP（a）和Cys-C水平在T2DM患者中呈显著正相关（r=0.796，P〈0.01）。结论：血清LP（a）和Cys-C是T2DM中引起冠心病（CHD）和糖尿病肾病（DN）的两个独立危险因素，且其检测水平呈正相关。T2DM患者进行血清LP（a）和Cys-C的定期联合检测，能够有效监测和延缓CHD和DN的发生。

Clinical application of LP(a) and Cys-c combined detection in T2DM

Objective：To study the relationship between LP（a） and Cys-C’level and the duration, glycemic control levels in the typeⅡdiabetes. Methods：The detection of LP （a） and Cys-C were analyzed between 150 T2DM patients and 30 healthy people. The 150 T2DM patients were divided into 4 groups according to duration：15 years groups.Results：There were significant difference （P15 years groups. Serum LP （a） and Cys-C levels in patients with T2DM showed a significant positive correlation （r=0.796, P〈0.01）.Conclusions：Serum LP （a） and Cys-C are two independent risk factor which could caused coronary heart disease and diabetic nephropathy （DN） , and its detection level was positively correlated. LP （a） and Cys-C combined detection is an effective means of monitoring in T2DM which could delay the incidence of coronary heart disease and DN.