鼻内翻性乳头状瘤中表皮生长因子及受体的表达与恶变的关系

目的探讨表皮生长因子(EGF)及其受体(EGFR)在鼻内翻性乳头状瘤(NIP)恶变前不同阶段中的表达情况及其生物学意义.方法应用免疫组织化学LSAB法检测NIP非典型增生的不同阶段及恶变组织中EGF、EGFR的表达情况.应用图像分析仪对染色结果进行定量分析.结果在上皮组织和间质结缔组织中EGF、EGFR阳性染色随着不典型增生程度的加重,其表达强度和范围也增加.中-重度不典型增生组织的表达强度与鳞状细胞癌组织接近.轻度不典型增生与NIP比较,中-重度不典型增生与轻度比较,EGF、EGFR表达差异均有统计学意义(均P<0.01).结论EGF参与了NIP的病理过程,EGF、EGFR的表达随肿瘤异型程度的增加而强度增加,其表达水平可以作为衡量NIP恶变倾向的指标之一.

The significance and expression of EGF and its receptor in nasal inverted papillomas and the correlation with malignant phenotype

OBJECTIVE: To determine the expression of epidermal growth factor (EGF) and its receptor in nasal inverted papillomas (NIP) and to clarify the function of EGF in the establishment of NIPs and the correlation with malignant phenotype. METHOD: The expression of EGF and its receptor EGFR were examined by immunohistochemistry using LSAB method in sections of NIP from 24 patients and squamous carcinoma from 4 patients. RESULT: Showed that all the epithelium in NIPs together with vascular and stroma adjacent to the epithelium, expressed different degree of EGF. The EGF, EGFR expression in epithelium was significantly stronger in severe atypical hyperplasia of NIP than that in mild atypical hyperplasia of NIP (P < 0.01). CONCLUSION: The results suggest that EGF, EGFR participate in the growth of NIPs, part of which shows the characteristics of containing plenty of blood vessels and being bloody in operation. The enhanted EGF, EGFR in the epithelium may be identified as one of the parameters of judging the propensity of NIPs malignant transformation.