移植肾亚临床排斥反应早期诊治的临床意义

目的 探讨对移植肾亚临床排斥反应进行早期诊断、早期治疗的临床意义。方法 选择术后3个月无临床症状、肾功能正常的同种异体肾移植患者96例（男54例，女42例），平均年龄为37．5岁（17～58岁），以彩色多普勒检查结果为诊断依据。分为正常组和异常组（亚临床排斥组），异常组给予甲基强的松龙冲击治疗和调整免疫抑制剂的剂量，随访观察两组移植肾的存活率。结果 经过3年的随访，两组病人移植肾的存活率无明显差异性。结论 早期诊断和治疗移植肾亚临床排斥反应。对提高移植肾的长期存活率有重要的临床意义。

Clinical significance of early diagnose and treatment of subclinical renal allograft rejection

Objective To explore the clinical significance of early diagnose and treatment of subclinical renal allograft rejection.Methods Ninety-six renal allograft recipients(54 male and 42 female)with normal renal function aged 17 to 58 years(mean 37.5 years)were included in this study.Early subclinical rejection was diagnosed 3 months after the transplantation by color Doppler examination.Results Patients with early subclinical rejection were given methylpredisolone followed by adjustment of immunosuppressive regimens,and no difference was observed in 3-year survival rate between these patients and those with normal renal allograft findings.Conclusion Early diagnosis and treatment of subclical renal allograft rejection is significant to improve renal allograft survival rate.