| 孕激素对癫痫大鼠大脑皮层,海马FOS蛋白表达的影响 |
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| 引用本文： | 王群,阮旭中.孕激素对癫痫大鼠大脑皮层,海马FOS蛋白表达的影响[J].中风与神经疾病杂志,1997,14(2):77-79. |
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| 作者姓名： | 王群 阮旭中 |
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| 作者单位： | 同济医科大学附属同济医院神经内科 |
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| 摘 要： | 本实验采用流式细胞免疫荧光技术对马桑内酯（ＣＬ）致痫及给予孕激素后再致痫大鼠大脑皮层、海马细胞ＦＯＳ表达进行定量检测。结果显示：ＣＬ致痫组大鼠皮层、海马ＦＯＳ表达的荧光指数（ＦＩ）和阳性细胞数较正常对照组明显增高（Ｐ＜０．０１）；给予孕酮（Ｐ）后再致痫组皮层、海马ＦＯＳ表达较单纯ＣＬ致痫组减少（Ｐ＜０．０１，Ｐ＜０．０５）。
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| 关 键 词： | 癫痫 FOS蛋白 孕激素 |
The effect of progestin on FOS protein expression in cerebral cortex and hippocampus of convulsive rats |
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| Wang Qun,Ruan Xuzhong,Li Zhenzhong,et al..The effect of progestin on FOS protein expression in cerebral cortex and hippocampus of convulsive rats[J].Journal of Apoplexy and Nervous Diseases,1997,14(2):77-79. |
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| Authors: | Wang Qun Ruan Xuzhong Li Zhenzhong |
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| Institution: | Wang Qun,Ruan Xuzhong,Li Zhenzhong,et al. Department of Neurology,Affiliated Tongji Hospital,Tongji Medical University,Wuhan,430030 |
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| Abstract: | Authers quantiatated FOS expression of cortical and hippocampal cells in the rats of convulsive group induced by CL without and with progesterone(P) administration by using flow cytometry and immunofluorescence techniques. The results demenstrated that in the rats of convulsive group induced by CL, the fluorescence index(FI) and the positive cell number of FOS expression in cerebral cortex and hippocampus, were significantly higher than those of normal control group (all P<0.01). In the rats of convulsive group after P administration, the FOS expression was decreased evidently (P<0.01, P<0.05), as compared with the convulsive group only induced by CL. |
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| Keywords: | Epilepsy FOS protein Progestin |
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