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| 人参皂甙调节大鼠自发睡眠脑电结构的机制 | |
| 引用本文： | 洪芬芳,王新,杨树龙,张大雷,杨蓓,吴磊.人参皂甙调节大鼠自发睡眠脑电结构的机制[J].基础医学与临床,2011,31(10). |
| 作者姓名： | 洪芬芳 王新 杨树龙 张大雷 杨蓓 吴磊 |
| 作者单位： | 1. 南昌大学 基础医学院 生理教研室,江西南昌330006;南昌大学 医学实验教学部,江西南昌330006 2. 南昌市西湖区疾控中心,江西南昌,330003 3. 南昌大学 基础医学院生理教研室,江西南昌,330006 |
| 基金项目： | 江西省教育厅科研基金(2008GJJ09038); 南昌大学引进博士科研启动基金(300304) |
| 摘 要： | 目的初步探索人参皂甙(GS)调节自发睡眠的作用机制。方法大鼠随机分为对照、GS低和高(10和100 mg/kg)剂量组。在大鼠体内植入无线发射器,术后每日1次灌胃给药,共6 d。第1(急性)和6天(慢性)给药后记录自由活动大鼠脑电活动12 h。于第1和6天取下丘脑组织用免疫印迹方法检测GABAAergic系统蛋白表达。结果 GS灌胃给药第1天,高剂量GS显著增加非快动眼睡眠(NREM)(8.002±0.427)h vs(6.363±0.542)h,P<0.05]和总睡眠时间(9.397±0.313)h vs(7.548±0.562)h,P<0.01],减少觉醒(2.463±0.288)h vs(4.376±0.572)h,P<0.01];GS低和高剂量都增强了下丘脑GABAA受体α、β亚型表达(P<0.05)。第6天,低、高剂量GS均显著提高NREM睡眠(7.587±0.174)h,(7.610±0.204)h vs(6.799±0.302)h,P<0.05]和总睡眠时间(8.974±0.191)h,(8.967±0.249)h vs(8.008±0.359)h,P<0.05],减少觉醒(3.13... |
| 关 键 词： | 人参皂甙 快动眼睡眠 非快动眼睡眠 脑电图 GABAA受体 |
Mechanisms underlie ginsenosides regulating spontaneous sleep architecture in rats |
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| HONG Fen-fang,WANG Xin,YANG Shu-long,ZHANG Da-lei,YANG Bei,WU Lei.Mechanisms underlie ginsenosides regulating spontaneous sleep architecture in rats[J].Basic Medical Sciences and Clinics,2011,31(10). | |
| Authors: | HONG Fen-fang WANG Xin YANG Shu-long ZHANG Da-lei YANG Bei WU Lei |
| Institution: | HONG Fen-fang1,2,WANG Xin3,YANG Shu-long1,ZHANG Da-lei1,YANG Bei1,WU Lei1(1.Dept.of Physiology of Basic Medical College,2.Dept.of Experimental Teaching,Nanchang University,Nanchang 330006,3.Disease Control Centers of Xihu District,Nanchang 330003,China) |
| Abstract: | Objective To study the underling mechanism of the effect of ginsenosides(GS) on spontaneous sleep.Methods Adult SD rats were randomly divided into the control,GS 10 mg/kg(low dose) and 100 mg/kg(high dose) groups.Rats were instrumented with sleep-wake recording electrodes.After recovery from surgical operation,rats were orally administered GS 10 mg/kg and 100 mg/kg or water once per day for 6 days.On GS administration day 1 and day 6,Polygraphic signs of undisturbed sleep-wake activities were recorded for 1... |
| Keywords: | ginsenosides rapid eye movement sleep non rapid eye movement sleep electroencephalogram GABAA receptor |
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