MHC-I expression in HTLV-1-positive and -negative cells |
| |
Authors: | Yoshida A Miyaura M Sakurai A Fukumori T Fujita M Akari H Adachi A |
| |
Affiliation: | Department of Virology, The University of Tokushima School of Medicine, Tokushima 770-8503, Japan. |
| |
Abstract: | The expression level of major histocompatibility class I (MHC-I) and the extent of down-regulation of MHC-I after an anti-MHC-I antibody treatment in numerous human T-cell leukemia virus type 1 (HTLV-1)-positive and -negative lymphocytic cell lines were examined. While there was no clear correlation between the expression level of MHC-I and the presence of HTLV-1 genome, a relatively low level of MHC-I down-regulation was generally induced in HTLV-1-positive cells by the antibody. The results may suggest the potential involvement of MHC-I in HTLV-1 leukemogenesis. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|