| 必克敏胶囊质量标准的研究 |
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| 引用本文： | 刘松青,代青,王章阳,张梅,赵映兰.必克敏胶囊质量标准的研究[J].中国药房,2001,12(12):746-747. |
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| 作者姓名： | 刘松青 代青 王章阳 张梅 赵映兰 |
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| 作者单位： | 第三军医大学西南医院药剂科, |
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| 摘 要： | 目的 :控制必克敏胶囊的质量。方法 :采用薄层层析法对处方中的麻黄进行定性研究 ,对成品乌头碱限量进行了检查 ;采用高效液相色谱法测定了必克敏胶囊中麻黄碱和伪麻黄碱的含量。结果 :麻黄碱和伪麻黄碱的标准曲线分别在0.02～0.10mg/ml(r=0.9993)和0.01～0.05mg/ml(r=0.9996)之间有较好的线性关系 ,麻黄碱和伪麻黄碱的加样回收率分别为 (101.4±1.78) %和(98.08±1.81) %。结论 :鉴别方法专属性强 ,定量方法灵敏 ,可有效地控制必克敏胶囊的质量
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| 关 键 词： | 必克敏胶囊 麻黄碱 伪麻黄碱 薄层层析法 高效液相色谱法 |
| 文章编号： | 1001-0408(2001)12-0746-02 |
| 修稿时间： | 2001年8月16日 |
Study on Quality Standard of Bikemin Capsule |
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| LIU Songqing,DAI Qing,WANG Zhangyang,ZHANG Mei,ZHAO Yinglan.Study on Quality Standard of Bikemin Capsule[J].China Pharmacy,2001,12(12):746-747. |
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| Authors: | LIU Songqing DAI Qing WANG Zhangyang ZHANG Mei ZHAO Yinglan |
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| Abstract: | OBJECTIVE:To establish the quality standard of Bikemin capsule to control the quality METHODS:TLC method was used for the identification of Ephedra sinica and the detection of limitation of aconitine in Bikemin capsule Ephedrine and pseudoephedrine in the capsule were determined by HPLC on C18 column with the detection wavelength at 215nm RESULTS:The standard curves of ephedrine and pseudoephedrine were linear in the ranges of 0 02～0 10mg/ml (r=0 9 993) and 0 01～0 05mg/ml(r=0 9 996)respectively The average recoveries were (101 4±1 78)% for ephedrine and (98 08±1 81)% for pseudoephedrine CONCLUSION:The identification method is specific and the determination method is sensitive The quality standard is suitable for control of quality of Bikemin capsule |
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| Keywords: | Bikemin capsule ephedrine pseudoephedrine TLC HPLC |
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