| SARS感染医务人员出院后免疫功能的变化 |
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| 引用本文： | 陈瑞,李建国,段朝晖,吴浩,胡晓文,魏菁,严海燕,江山平,张蔚.SARS感染医务人员出院后免疫功能的变化[J].中华医院感染学杂志,2003,13(11):1053-1054. |
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| 作者姓名： | 陈瑞 李建国 段朝晖 吴浩 胡晓文 魏菁 严海燕 江山平 张蔚 |
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| 作者单位： | 中山大学附属第二医院,广东,广州,510120 |
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| 基金项目： | 广东省科技厅科研基金资助项目 (A0 0 2 0 0 30 0 5 ) |
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| 摘 要： | 目的 探讨SARS患者出院2个月后细胞免疫和体液免疫功能的变化。方法 分别采用流式细胞仪和散射免疫比浊仪检测31例SARS出院2个月患者外周血T淋巴细胞亚群和免疫球蛋白水平，并与正常对照组比较。结果与对照组相比，SARS组CD3^-、CD8^ 细胞百分数升高，CD4^-细胞百分数无明显改变，CD4^-／CD8^ 比值和NK细胞百分数下降；IgA水平明显降低，IgG、IgM、C3、C4水平差异无显著性。结论 SARS患者出院2个月后仍存在细胞免疫和体液免疫功能的低下。
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| 关 键 词： | SARS 细胞免疫 体液免疫 T淋巴细胞亚群 |
| 文章编号： | 1005-4529(2003)11-1053-02 |
| 修稿时间： | 2003年6月20日 |
Changes in Immunity among SARS Patients Who Work in Hospital |
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| CHEN Rui,LI Jian-guo,DUAN Zhao-hui,WU Hao,HU Xiao-wen,WEI Jing,YAN Hai-yan,JIANG Shan-ping,ZHANG Wei.Changes in Immunity among SARS Patients Who Work in Hospital[J].Chinese Journal of Nosocomiology,2003,13(11):1053-1054. |
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| Authors: | CHEN Rui LI Jian-guo DUAN Zhao-hui WU Hao HU Xiao-wen WEI Jing YAN Hai-yan JIANG Shan-ping ZHANG Wei |
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| Abstract: | OBJECTIVE To investigate the changes in immunity among 31 SARS cases 2 months after discharge. METHODS T Lymphocyte subsets were detected by using flow cytometry and serum globulin was detected by turbidity method. RESULTS Compared with the control group, the proportion of CD 3 +, CD 8 + cell increased significantly, CD 4 + cell had no significant change, ratio CD 4 +/CD 8 + and NK cell decreased significantly. The level of IgA decreased significantly, no significant change was seen in IgG, IgM, C3, C4. CONCLUSIONS Two months after discharge, the cellular immunity and humoral immunity were lower in SARS cases. |
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| Keywords: | SARS Cellular immunity Humoral immunity T lymphocyte subsets |
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