乳腺癌保乳手术的治疗及预后

目的探讨乳腺癌保乳手术的方式和预后。方法回顾性分析笔者所在2所医院10年间保乳治疗69例原发性乳腺癌患者的临床资料，包括保乳术不放疗和保乳术加放疗、化疗和激素治疗。随访12～140个月。结果保乳手术未放疗组3年复发率11．54％（3／26），显著高于手术加放疗组3．03％（1／33）（P〈0．05）。腋窝淋巴结阳性的保乳手术未化疗者，其5年远处转移率（50．0％）高于手术加化疗组（11．1％）（P〈0．05）。结论保乳术后应进行放疗；年轻、淋巴结阳 性、组织学分级Ⅲ级者应辅助化疗。

Breast conserving therapy for breast cancer and its prognosis

Objective To explore the effect of breast-conserving therapy for breast cancer(BCT) and its prognosis. Methods The clinical data of 69 cases of BCT admitted from January 1992 to December 2003 were analyzed retrospectively. The cases included those who had BCT without radiotherapy and those who had BCT with adjuvant radiotherapy, chemotherapy and hormonal therapy. The patients were followed up for 12 to 140 months. Results The 3-year recurrence rate for patients without radiotherapy (11.54%) was higher than that for those with radiotherapy (3.03%) (P<0.05). In node-positive patients, the 5-year (distant) metastasis rate for patients without chemotherapy(49.21%) was higher than that for those with (chemotherapy) (7.81%) (P<0.05) . Conclusions Radiotherapy must be given after BCT. Patients who are young or node-positive, or have histological grade III tumor should receive adjuvant chemotherapy.