| 环孢霉素A对大鼠单个核细胞雄激素和雌激素受体的影响及意义 |
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| 引用本文： | 赵瑛,刘志民.环孢霉素A对大鼠单个核细胞雄激素和雌激素受体的影响及意义[J].标记免疫分析与临床,1996,3(2):93-95,89. |
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| 作者姓名： | 赵瑛 刘志民 |
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| 作者单位： | [1]第二军医大学长征医院神经科 [2]内分泌科 |
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| 摘 要： | 研究了环孢霉素Ａ（ＣａＡ）、环磷酰胺（ＣＴＸ）及甲基强的松龙（ＭＰ）对大鼠单个核细胞（ＭＮＬ）雄激素受体（ＡＲ）及雌激素受体（ＥＲ）的影响。结果表明：静注ＣｓＡ２０ｍｇ／ｋｇ，ＥＲ明显降低，３ｈ作用达高峰，持续低水平达８ｈ；而ＡＲ无明显影响。静注ＣａＡ１００ｍｇ／ｋｇ用ＣＴＡ和ＭＰ使ＡＲ、ＥＲ均明显降低。而ＣＴＸ和ＭＰ使ＥＲ降低，也使ＡＲ降低，故ＣｓＡ免疫抑制作用优于ＣＴＸ和ＭＰ。
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| 关 键 词： | 环孢霉素A 受体 雄激素 雌激素 大鼠 MNL |
Effect of Cyclosporin A on Androgen and Estradial Receptor of Mononuclear Leukocytes of Rats and Its Significance |
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| Zhao Ying, Liu Zhimin, Shao Fuyuan,et al..Effect of Cyclosporin A on Androgen and Estradial Receptor of Mononuclear Leukocytes of Rats and Its Significance[J].Labeled Immunoassays and Clinical Medicine,1996,3(2):93-95,89. |
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| Authors: | Zhao Ying Liu Zhimin Shao Fuyuan |
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| Abstract: | Effect of Cyclospotin A (CsA), Cyclosphamide (CTX) and Medrol (MP) on estradial receptor (ER) and androgen receptor (AR) of rat peripheral mononuclear leukocytes (MNL) were studied in vivo by radioligand binding assay. The binding capacity of ER and AR was not changed at a concentration of 5mg/kg. When the concentration of CsA was 20mg/kg,the binding capacity of ER decreased by 50% and that of AR was not changed. But both CTX and MP lowered the binding capacity of ER and AR. Combined administration of CsA,CTX and MP decreased by 55% the binding capacity of ER. The findings suggest that CsA may reverse the inhibition of CTX and MP on AR and demonstrates a better therapeutic effect in comparison with CTX and MP. |
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| Keywords: | Cyclosporin Receptors estrogen Receptors androgen Rats inbred strains |
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