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Alkylation mutagenesis in Saccharomyces cerevisiae: lack of evidence for an adaptive response |
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| Authors: | Renata Polakowska Giuditta Perozzi Louise Prakash |
| Institution: | (1) Department of Radiation Biology and Biophysics, University of Rochester School of Medicine, 14642 Rochester, NY, USA;(2) Department of Biology, University of Rochester, 14627 Rochester, NY, USA;(3) Present address: Department of Genetics, University of Rochester School of Medicine, 14642 Rochester, NY, USA |
| Abstract: | Summary We have found no evidence for an adaptive response for either lethality or mutagenesis following treatment of Saccharomyces cerevisiae with N-methyl-N -nitro-N-nitrosoguanidine (MNNG). The rad6 and rad52 mutants of S. cerevisiae are highly defective in MNNG and ethyl methanesulfonate induced mutagenesis of both stationary and exponential phase cells. These and other observations indicate that the mechanisms of repair of alkylation damage and mutagenesis differ markedly between S. cerevisiae and Escherichia coli. |
| Keywords: | Alkylation mutagenesis Adaptive response rad6 rad52 Yeast |
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