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Effects of light on human melatonin production and the human circadian system

Authors:	Alfred J Lewy MD PhD

Institution:	Director, Sleep and Mood Disorders Laboratory Departments of Psychiatry, Pharmacology and Ophthalmology Oregon Health Sciences University Portland, Oregon 97201, USA

Abstract:	1. 1. Bright artificial light appears to have similar effects in humans as in other species. 2. 2. Bright light may therefore be used as a clinical research tool and as a therapeutic modality for treating certain biological rhythm disorders. 3. 3. Melatonin production appears to be a particularly useful “biological marker” for the human endogenous circadian pacemaker and the effects of light. Author Keywords: light; circadian rhythms; seasonal rhythms; photoperiodism; melatonin secretion; pineal gland; manic-depressive patients; seasonal affective disorder; blind subjects

Keywords:	light circadian rhythms seasonal rhythms photoperiodism melatonin secretion pineal gland manic-depressive patients seasonal affective disorder blind subjects
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