25-羟维生素D与儿童1型糖尿病及酮症酸中毒的相关性研究

目的 探讨血清25-羟维生素D[25-(OH)D]水平与儿童1型糖尿病及酮症酸中毒(DKA)的相关性。方法 选取2006年1 月—2009年12月在本院治疗的152例患儿，其中52例为首次发病的1型糖尿病患儿，其余100例按糖尿病标准排除糖尿病。对52例1型糖尿病患儿的临床和实验室资料进行研究，分析血清25-(OH)D水平与儿童1型糖尿病及酮症酸中毒的关系。结果 1型糖尿病儿童血清25-(OH)D 的平均水平为(63.67±28.41)nmol·L^-1，显著低于非糖尿病儿童(P<0.05)，差异有统计学意义。DKA患儿的血清25-(OH)D 的平均水平为(58.63±27.79)nmol·L^-1，显著低于非DKA患儿(P<0.05)，差异有统计学意义。结论 血清 25-(OH)D的水平较低可能会增加儿童1型糖尿病以及发生酮症酸中毒的风险。

Correlation between Serum 25-(OH)D Levels and Children with Type 1 Diabetes Mellitus and Diabetic Ketoacidosis(DKA)

OBJECTIVE To investigate the correlation between levels of serum 25-(OH)D and children with type 1 diabetes mellitus and diabetic ketoacidosis(DKA). METHODS Fifty-two cases who initially fell ill with type 1 diabetes mellitus were selected from 152 cases who stayed in our hospital from January 2006 to November 2009. The other 100 children were excluded from type 1 diabetes mellitus according to following standard. Clinical and laboratory data of 52 cases with type 1 diabetes mellitus was studied. The relationship between levels of serum 25-(OH)D and children with type 1 diabetes mellitus and DKA was acquired. RESULTS The serum 25-(OH)D level of children with type 1 diabetes mellitus was(63.67±28.41)nmol·L^-1 which was significantly lower than that excluded from type 1 diabetes mellitus(P<0.05). The average serum 25-(OH)D level of DKA children was (58.63±27.79)nmol·L^-1 which was statistically lower than non-DKA cases. CONCLUSION The low level of serum 25-(OH)D maybe increase the risk of development of type 1 diabetes mellitus and DKA.