| 4-色满酮Mannich碱类化合物的合成及其抗炎活性 |
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| 引用本文： | 胡春,肖高铿,于新章,王永永,付守廷,计志忠,刘百里. 4-色满酮Mannich碱类化合物的合成及其抗炎活性[J]. 中国药物化学杂志, 2004, 14(4): 209-214 |
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| 作者姓名： | 胡春 肖高铿 于新章 王永永 付守廷 计志忠 刘百里 |
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| 作者单位： | 沈阳药科大学制药工程学院,辽宁,沈阳,110016 |
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| 基金项目： | 吉林省沈阳市科技局科技基金 |
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| 摘 要： | 目的设计合成一些4-色满酮Mannich类化合物,并且考察其抗炎活性.方法以取代的4-色满酮为原料,经过Mannich反应合成4-色满酮Mannich碱类化合物,并测定了目标化合物的抗炎活性.结果合成了17种4-色满酮Mannich碱类化合物,并经元素分析、红外光谱、核磁共振氢谱确证这些化合物的结构,药理活性筛选结果表明:大多数化合物具有显著的抗炎活性.
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| 关 键 词： | 药物化学 制备 Mannich反应 4-色满酮 Mannich碱 抗炎活性 |
| 文章编号： | 1005-0108(2004)04-0209-06 |
Synthesis and anti-inflammatory activity of the Mannich bases of 4-chromanones |
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| HU Chun,XIAO Gao-keng,YU Xing-zhang,WANG Yong-yong,FU Shou-ting,JI Zhi-zhong,LIU Bai-li. Synthesis and anti-inflammatory activity of the Mannich bases of 4-chromanones[J]. Chinese Journal of Medicinal Chemistry, 2004, 14(4): 209-214 |
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| Authors: | HU Chun XIAO Gao-keng YU Xing-zhang WANG Yong-yong FU Shou-ting JI Zhi-zhong LIU Bai-li |
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| Abstract: | Aim To design and synthesize some Mannich bases of 4-chromanones and study their anti-inflammatory activity.Methods The target Mannich bases of 4-chromanones were synthesized from 4-chromanones by using the Mannich reaction and their anti-inflammatory activity was evaluated with the model of xylene-induced ear edema in mice in vivo .Results Senventeen Mannich bases of 4-chromanones were synthesized and characterized by elemental analysis,infrared spectra and proton NMR spectra,some of these compounds exhibit potent anti-inflammatory activity. |
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| Keywords: | medicinal chemistry 4-chromanone Mannich base preparation anti-inflammatory activity |
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