DSA引导下肋间动脉栓塞法分度建立犬脊髓缺血模型及扩散加权成像初步研究

目的 采用DSA引导下肋间动脉栓塞法分度建立犬脊髓缺血模型并进行磁共振扩散成像（DWI）的初步应用。方法 9只犬采用完全随机分组法分为3组，按照不同配比的碘油栓塞剂栓塞犬9-11肋间动脉，观察其神经功能、病理变化，并在1.5T磁共振仪进行常规MRI和DWI。结果 除1例栓塞失败外，余均成功建模。轻度组（3例）损伤较轻，肌力3-5级之间，有一定恢复性，病灶范围2个椎体左右，中度组（3例）均表现截瘫，肌力0-1级，伴大小便失禁，病灶范围在3-4个椎体间；重度组（2例）均截瘫，肌力0级，大小便失禁，病灶范围〉4个椎体。常规MRI和DWI均表现为病灶高信号。结论 采用不同配比的碘油栓塞剂可以分度建立犬脊髓缺血模型，并可以在1．5T磁共振仪进行DWI，为进一步脊髓缺血研究奠定了基础。

DSA-guided embolization in establishing different canine spinal cord ischemia models and relevant diffusion-weighted imaging study

Objective To evaluate DSA-guided embolization in establishing different spinal cord ischemia models of canine and relevant diffusion-weighted imaging(DWI) application.Methods Nine canines were randomly divided into three groups with different matching of lipiodol and diatrizoate meglumine which were injected into bilateral intercostal arteries at 9-11 level guided by DSA monitor. Then observe the changes of motor function and pathologic findings,especially perform routine MRI and DWI by a 1.5 T MR system.Results Except one case,8 embolization models were established successfully.Among three groups,slight-group got slight injury and muscle power was about 3-5 grade and range of injury was about two vertebra distance;medium-group presented obvious paraplegia and muscle power was 0-1 grade and range of injury was between 3-4 vertebra distance;severe-group showed greater severity and larger range of injury.All lesions presented high signals at routine MRI and DWI.Conclusion Using different matching of lipiodol and diatrizoate meglumine can establish different spinal cord ischemia models of canine by DSA-guided embolzation and DWI can be performed successfully by 1.5 T MR system,which may be a good method for advanced study of spinal cord ischemia.