血清C反应蛋白及D-二聚体水平与社区获得性肺炎的相关性分析

目的:探究血清C反应蛋白(CRP)及D-二聚体(D-D)水平与社区获得性肺炎的相关性。方法:收集124例社区获得性肺炎患者,根据肺炎严重程度指数(PSI)和社区获得性肺炎(CURB-65)评分分别进行分组,对比不同病情程度患者的血清CRP及D-D水平差异,分析CRP及D-D水平与PSI、CURB-65评分的相关性。结果:根据PSI分级患者分为重度组35例,中度组49例,低度组40例。血清CRP及D-D水平重度组中度组低度组,组间比较差异有统计学意义(均P 0. 05)。根据CURB-65评分患者分为高危组26例,中危组51例,低危组47例。血清CRP及D-D水平高危组中危组低危组,组间比较差异有统计学意义(均P 0. 05)。相关性分析结果显示,CRP与PSI分级、CURB-65评分均有显著相关(r=0. 374,0. 405,P 0. 05),D-D与PSI分级、CURB-65评分均有显著相关(r=0. 359,0. 392,P 0. 05)。结论:CRP及D-D水平与社区获得性肺炎患者的病情严重程度明显相关,可作为评估此类疾病严重程度的辅助指标。

Analysis of the relationship between C - reactive protein and D - dimer and community - acquired pneumonia

Objective: To investigate the correlation between C-reactive protein (CRP) and D-dimer (D-D) levels with community-acquired pneumonia. Methods: A total of 124 patients with community-acquired pneumonia were enrolled in our study from 2014.1 to 2016.12, and the patients were divided into three groups according to the Pneumonia severity index (PSI) and the CURB-65 score. The serum levels of CRP and DD were compared between patients with different disease levels. And the correlations between CRP and DD levels with PSI and CURB-65 scores were analyzed. Results: According to PSI grading, patients were divided into severe group (35 cases), moderate group (49 cases), and low group (40 cases); the results of serum CRP and DD levels in three groups were severe group> moderate group> low group, and the differences between the groups were statistically (P<0.05). According to CURB-65 score, 26 patients were divided into high risk group, 51 patients in middle risk group and 47 patients with low risk group. Serum CRP and DD levels were high risk group> middle risk group> low risk group (P <0.05). The correlation analysis showed that CRP was significantly correlated with PSI grade and CURB-65 score (r = 0.374,0.405, P <0.05), and the difference between the two groups was statistically significant (r = 0.359, 0.392, P <0.05). Conclusion: CRP and D-D levels are significantly correlated with the degree of disease and risk of community-acquired pneumonia, which can be used as an index to evaluate the severity of these diseases.