Interleukin-15-deficient mice develop protective immunity to Toxoplasma gondii |
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| Authors: | Lieberman Linda A Villegas Eric N Hunter Christopher A |
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| Affiliation: | Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA. |
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| Abstract: | Previous studies have suggested an important role for interleukin-15 (IL-15) in resistance to and memory for Toxoplasma gondii infection. The studies presented here reveal that IL-15 is not required for infection-induced expansion of NK or CD8+ T cells. Furthermore, IL-15-/- mice develop long-term protective immunity to this pathogen. |
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